ArticleMetabolism: clinical and experimental2007
The adipose cell lineage is not intrinsically insulin resistant in polycystic ovary syndrome.
Article in Metabolism: clinical and experimental, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.
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Who cites it
22 citing papers in PubMed, 1 synthesis or guideline pooled it, 52 citations in OpenAlex.
- Circulating inflammatory markers in polycystic ovary syndrome: a systematic review and metaanalysis.Fertility and sterility · 2011Pooled it
- On the Intimate Relationship of Adiposity to Polycystic Ovary Syndrome.The Journal of clinical endocrinology and metabolism · 2025Review
- Increased Skeletal Muscle Fiber Cross-Sectional Area, Muscle Phenotype Shift, and Altered Insulin Signaling in Rat Hindlimb Muscles in a Prenatally Androgenized Rat Model for Polycystic Ovary Syndrome.International journal of molecular sciences · 2020Article
- Developmental programming of insulin resistance: are androgens the culprits?The Journal of endocrinology · 2020Review
- Insulin signaling displayed a differential tissue-specific response to low-dose dihydrotestosterone in female mice.American journal of physiology. Endocrinology and metabolism · 2018Article
- Dynamic Change in Insulin Resistance Induced by Free Fatty Acids Is Unchanged Though Insulin Sensitivity Improves Following Endurance Exercise in PCOS.Frontiers in endocrinology · 2018Article
- Low-Dose Dihydrotestosterone Drives Metabolic Dysfunction via Cytosolic and Nuclear Hepatic Androgen Receptor Mechanisms.Endocrinology · 2017Article
- The Pathogenesis of Polycystic Ovary Syndrome (PCOS): The Hypothesis of PCOS as Functional Ovarian Hyperandrogenism Revisited.Endocrine reviews · 2016 · on this mapReview
- Endocrine causes of nonalcoholic fatty liver disease.World journal of gastroenterology · 2015Review
- Comprehensive assessment of expression of insulin signaling pathway components in subcutaneous adipose tissue of women with and without polycystic ovary syndrome.Journal of clinical & translational endocrinology · 2015Article
- Identification of differentially expressed microRNAs in the ovary of polycystic ovary syndrome with hyperandrogenism and insulin resistance.Chinese medical journal · 2015Article
- Review of nonalcoholic fatty liver disease in women with polycystic ovary syndrome.World journal of gastroenterology · 2014Review
- Association between follicular fluid leptin and serum insulin levels in nonoverweight women with polycystic ovary syndrome.BioMed research international · 2014Article
- Sheep models of polycystic ovary syndrome phenotype.Molecular and cellular endocrinology · 2013Review
- Polycystic ovarian syndrome in patients with lipodystrophy: Report of 2 cases with review of literature.Indian journal of endocrinology and metabolism · 2012Article
- Steroidogenic regulatory factor FOS is underexpressed in polycystic ovary syndrome (PCOS) adipose tissue and genetically associated with PCOS susceptibility.The Journal of clinical endocrinology and metabolism · 2012Article
- Adipose tissue dysfunction in polycystic ovary syndrome.Current diabetes reports · 2011Review
- Article
- Evidence that obesity and androgens have independent and opposing effects on gonadotropin production from puberty to maturity.Brain research · 2010Review
- Developmental programming: differential effects of prenatal testosterone excess on insulin target tissues.Endocrinology · 2010Article
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
Abstract
Selective resistance to the effects of insulin on glucose metabolism in skeletal muscle and adipose tissue is a key feature of polycystic ovary syndrome (PCOS). The pathogenesis of insulin resistance in skeletal muscle in PCOS involves interaction of in vivo environmental factors with intrinsic defects in insulin signaling. We aimed to determine whether (1) intrinsic defects in insulin action/signaling and cytokine secretion were present in adipose cells in PCOS and (2) insulin resistance can be induced in control adipose cells by culture in medium conditioned by insulin-resistant PCOS fibroblasts. Subcutaneous abdominal preadipocytes from obese women with PCOS (n = 7) and age- and body mass index-matched controls (n = 5) were cultured for several generations in vitro. Basal and insulin-stimulated glycogen synthesis and basal glucose transport did not differ in the preadipocytes from women with PCOS and controls. Abundance of insulin receptor (IR) beta subunit, insulin receptor substrate (IRS) 1 and 2, p85 subunit of phosphatidylinositol 3-kinase, and extracellular signal-regulated kinase (ERK)1/2 activation did not differ. Secretion of tumor necrosis factor alpha and interleukin 6 did not differ. Insulin action on glycogen synthesis in control preadipocytes was not altered by coculture with or growth in media conditioned by PCOS skin fibroblasts with constitutive serine phosphorylation of IRbeta subunit (IR ser+), indicating that IR ser+ cells do not secrete an insulin resistance-inducing factor. We conclude that in contrast to skeletal muscle and skin fibroblasts, there is no evidence for intrinsic defects in insulin signaling in the PCOS adipose cell lineage, indicating that insulin resistance in these cells is likely due to factors in the in vivo environment.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.