ArticleNeuropsychopharmacology : official publication of the American College of Neuropsychopharmacology2008
Effects of cocaine and MDMA self-administration on serotonin transporter availability in monkeys.
Article in Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
22 citing papers in PubMed, 64 citations in OpenAlex.
- Effects of access condition on substance use disorder-like phenotypes in male and female rats self-administering MDPV or cocaine.Drug and alcohol dependence · 2024Article
- Effects of access condition on substance use disorder-like phenotypes in male and female rats self-administering MDPV or cocaine.bioRxiv : the preprint server for biology · 2024Article
- Prescription psychostimulants for cocaine use disorder: A review from molecular basis to clinical approach.Addiction biology · 2023Review
- Serotonin transporter protein in autopsied brain of chronic users of cocaine.Psychopharmacology · 2020Article
- Stress as a Risk Factor for Substance Use Disorders: A Mini-Review of Molecular Mediators.Frontiers in behavioral neuroscience · 2018Review
- The effects of ecstasy on neurotransmitter systems: a review on the findings of molecular imaging studies.Psychopharmacology · 2016Review
- Changes in serotonin transporter (5-HTT) gene expression in peripheral blood cells after MDMA intake.Psychopharmacology · 2015Article
- Serotonin 5-HT2 receptor interactions with dopamine function: implications for therapeutics in cocaine use disorder.Pharmacological reviews · 2015Review
- Serotonin and mental disorders: a concise review on molecular neuroimaging evidence.Clinical psychopharmacology and neuroscience : the official scientific journal of the Korean College of Neuropsychopharmacology · 2014Review
- PET studies in nonhuman primate models of cocaine abuse: translational research related to vulnerability and neuroadaptations.Neuropharmacology · 2014Review
- Environmental modulation of drug taking: Nonhuman primate models of cocaine abuse and PET neuroimaging.Neuropharmacology · 2014Review
- Monoamine transporter inhibitors and substrates as treatments for stimulant abuse.Advances in pharmacology (San Diego, Calif.) · 2014Review
- Identifying the molecular basis of inhibitory control deficits in addictions: neuroimaging in non-human primates.Current opinion in neurobiology · 2013Article
- Neurobiological changes mediating the effects of chronic fluoxetine on cocaine use.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2012Article
- Neuroimaging and drug taking in primates.Psychopharmacology · 2011Review
- Nonhuman primate positron emission tomography neuroimaging in drug abuse research.The Journal of pharmacology and experimental therapeutics · 2011Article
- Serotonin transporter binding and genotype in the nonhuman primate brain using [C-11]DASB PET.NeuroImage · 2009Article
- Differential changes in mesolimbic dopamine following contingent and non-contingent MDMA self-administration in mice.Psychopharmacology · 2009Article
- Blockade of the serotonin 5-HT2A receptor suppresses cue-evoked reinstatement of cocaine-seeking behavior in a rat self-administration model.Behavioral neuroscience · 2009Article
- Serotonergic mechanisms in addiction-related memories.Behavioural brain research · 2008Review
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
Although serotonin (5-HT) can interact with dopamine (DA) systems to modulate the subjective and reinforcing effects of psychostimulants such as cocaine and 3,4-methyldioxymethamphetamine (MDMA, ecstasy), the long-term effects of exposure to psychostimulants on brain 5-HT systems are not well characterized. The present study assessed 5-HT transporter (SERT) availability using positron emission tomography (PET) in rhesus monkeys with the SERT-specific radioligand [(11)C]3-amino-4-(2-dimethylaminomethyl-phenylsulfanyl)-benzonitrile (DASB). SERT availability was assessed in regions of interest including the caudate nucleus, putamen, anterior cingulate cortex, and cerebellum. [(11)C]DASB distribution volume ratios (DVRs) were calculated using the cerebellum as the reference region. DVRs were calculated in control monkeys and in cocaine or MDMA self-administering monkeys approximately 24 h after the last self-administration (SA) session. SERT availability did not differ between monkeys with a history of MDMA SA and control monkeys in any region examined. In contrast, monkeys with a history of cocaine SA showed significantly higher levels of SERT availability in the caudate nucleus and putamen compared to control subjects. These results suggest that chronic SA of cocaine, but not MDMA, leads to alterations in serotonergic function in brain areas relevant to drug abuse. The higher level of SERT availability in cocaine-experienced monkeys may lead to a reduced inhibitory tone of 5-HT on the DA system, which may explain, in part, differences in the abuse liability between cocaine and MDMA.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.