ArticleMolecular biology of the cell2007
The conserved Spc7 protein is required for spindle integrity and links kinetochore complexes in fission yeast.
Article in Molecular biology of the cell, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
23 citing papers in PubMed, 35 citations in OpenAlex.
- Proteomic Analysis Revealed that DVL, a Lectin Purified fromACS omega · 2025Article
- Multimerization of a disordered kinetochore protein promotes accurate chromosome segregation by localizing a core dynein module.The Journal of cell biology · 2024Article
- A Functional Yeast-Based Screen Identifies the Host Microtubule Cytoskeleton as a Target of NumerousInternational journal of molecular sciences · 2023Article
- Inositol Pyrophosphate-Controlled Kinetochore Architecture and Mitotic Entry inJournal of fungi (Basel, Switzerland) · 2022Article
- The microtubule- and PP1-binding activities ofMolecular biology of the cell · 2022Article
- The Kinetochore Protein Spc105, a Novel Interaction Partner of LaeA, Regulates Development and Secondary Metabolism inFrontiers in microbiology · 2019Article
- The novel microtubule-associated CAP-glycine protein Cgp1 governs growth, differentiation, and virulence of Cryptococcus neoformans.Virulence · 2018Article
- Inositol Pyrophosphate Kinase Asp1 Modulates Chromosome Segregation Fidelity and Spindle Function in Schizosaccharomyces pombe.Molecular and cellular biology · 2016Article
- KNL1: bringing order to the kinetochore.Chromosoma · 2014Review
- A chaperone-assisted degradation pathway targets kinetochore proteins to ensure genome stability.PLoS genetics · 2014Article
- Sos7, an essential component of the conserved Schizosaccharomyces pombe Ndc80-MIND-Spc7 complex, identifies a new family of fungal kinetochore proteins.Molecular and cellular biology · 2012Article
- MPS1/Mph1 phosphorylates the kinetochore protein KNL1/Spc7 to recruit SAC components.Nature cell biology · 2012Article
- Microtubule binding by KNL-1 contributes to spindle checkpoint silencing at the kinetochore.The Journal of cell biology · 2012Article
- Spatiotemporal dynamics of Spc105 regulates the assembly of the Drosophila kinetochore.Open biology · 2012Article
- Spindle checkpoint silencing requires association of PP1 to both Spc7 and kinesin-8 motors.Developmental cell · 2011Article
- Protein interaction domain mapping of human kinetochore protein Blinkin reveals a consensus motif for binding of spindle assembly checkpoint proteins Bub1 and BubR1.Molecular and cellular biology · 2011Article
- Mechanisms of force generation by end-on kinetochore-microtubule attachments.Current opinion in cell biology · 2010Review
- Overcoming inhibition in the spindle checkpoint.Genes & development · 2009Review
- Roles for the conserved spc105p/kre28p complex in kinetochore-microtubule binding and the spindle assembly checkpoint.PloS one · 2009Article
- Intrakinetochore localization and essential functional domains of Drosophila Spc105.The EMBO journal · 2009Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Spc7, a member of the conserved Spc105/KNL-1 family of kinetochore proteins, was identified as an interaction partner of the EB1 homologue Mal3. Spc7 associates with the central centromere region of the chromosome but does not affect transcriptional silencing. Here, we show that Spc7 is required for the integrity of the spindle as well as for targeting of MIND but not of Ndc80 complex components to the kinetochore. Spindle defects in spc7 mutants were severe ranging from the inability to form a bipolar spindle in early mitosis to broken spindles in midanaphase B. spc7 mutant phenotypes were partially rescued by extra alpha-tubulin or extra Mal2. Thus, Spc7 interacts genetically with the Mal2-containing Sim4 complex.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.