ArticleMolecular biology of the cell2007
MTOC reorientation occurs during FcgammaR-mediated phagocytosis in macrophages.
Article in Molecular biology of the cell, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 39 citations in OpenAlex.
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- Microtubules regulate tissue-level navigation in skin-resident macrophages.Journal of cell science · 2025Article
- Ninein promotes F-actin cup formation and inward phagosome movement during phagocytosis in macrophages.Molecular biology of the cell · 2024Article
- Endoplasmic reticulum-Phagosome contact sites from the cradle to the grave.Frontiers in cell and developmental biology · 2022Review
- Spatial distribution of IL4 controls iNKT cell-DC crosstalk in tumors.Cellular & molecular immunology · 2020Article
- Modulation of Immune Responses by Particle Size and Shape.Frontiers in immunology · 2020Review
- LFA-1 Engagement Triggers T Cell Polarization at the HIV-1 Virological Synapse.Journal of virology · 2016Article
- Comparative Anatomy of Phagocytic and Immunological Synapses.Frontiers in immunology · 2016Review
- Sex differences in the acute in vivo effects of different human SP-A variants on the mouse alveolar macrophage proteome.Journal of proteomics · 2014Article
- Article
- Human immunodeficiency syndromes affecting human natural killer cell cytolytic activity.Frontiers in immunology · 2014Review
- The microglial activation state regulates migration and roles of matrix-dissolving enzymes for invasion.Journal of neuroinflammation · 2013Article
- Cellular localization of NLRP3 inflammasome.Protein & cell · 2013Article
- Dedicator of cytokinesis 8 interacts with talin and Wiskott-Aldrich syndrome protein to regulate NK cell cytotoxicity.Journal of immunology (Baltimore, Md. : 1950) · 2013Article
- Modular organization of the mammalian Golgi apparatus.Current opinion in cell biology · 2012Review
- Sex differences in the response of the alveolar macrophage proteome to treatment with exogenous surfactant protein-A.Proteome science · 2012Article
- Review
- Interactions between Leishmania braziliensis and Macrophages Are Dependent on the Cytoskeleton and Myosin Va.Journal of parasitology research · 2012Article
- Antigen processing and remodeling of the endosomal pathway: requirements for antigen cross-presentation.Frontiers in immunology · 2012Article
- In vivo rescue of alveolar macrophages from SP-A knockout mice with exogenous SP-A nearly restores a wild type intracellular proteome; actin involvement.Proteome science · 2011Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cell polarization is essential for targeting signaling elements and organelles to active plasma membrane regions. In a few specialized cell types, cell polarity is enhanced by reorientation of the MTOC and associated organelles toward dynamic membrane sites. Phagocytosis is a highly polarized process whereby particles >0.5 microm are internalized at stimulated regions on the cell surface of macrophages. Here we provide detailed evidence that the MTOC reorients toward the site of particle internalization during phagocytosis. We visualized MTOC proximity to IgG-sRBCs in fixed RAW264.7 cells, during live cell imaging using fluorescent chimeras to label the MTOC and using frustrated phagocytosis assays. MTOC reorientation in macrophages is initiated by FcgammaR ligation and is complete within 1 h. Polarization of the MTOC toward the phagosome requires the MT cytoskeleton and dynein motor activity. cdc42, PI3K, and mPAR-6 are all important signaling molecules for MTOC reorientation during phagocytosis. MTOC reorientation was not essential for particle internalization or phagolysosome formation. However Golgi reorientation in concert with MTOC reorientation during phagocytosis implicates MTOC reorientation in antigen processing events in macrophages.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.