ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2007
Shape change controls supporting cell proliferation in lesioned mammalian balance epithelium.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
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Who cites it
35 citing papers in PubMed, 53 citations in OpenAlex.
- Stiffening of Circumferential F-Actin Bands Correlates With Regenerative Failure and May Act as a Biomechanical Brake in the Mammalian Inner Ear.Frontiers in cellular neuroscience · 2022Article
- Dynamic patterns of YAP1 expression and cellular localization in the developing and injured utricle.Scientific reports · 2021Article
- Research progress on flat epithelium of the inner ear.Physiological research · 2020Review
- Knockdown ofAging · 2020Article
- YAP Mediates Hair Cell Regeneration in Balance Organs of Chickens, But LATS Kinases Suppress Its Activity in Mice.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Article
- EGF and a GSK3 Inhibitor Deplete Junctional E-cadherin and Stimulate Proliferation in the Mature Mammalian Ear.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Article
- Three-dimensional Organotypic Cultures of Vestibular and Auditory Sensory Organs.Journal of visualized experiments : JoVE · 2018Article
- Cell proliferation during hair cell regeneration induced by MathNeural regeneration research · 2018Article
- Junctional E-cadherin/p120-catenin Is Correlated with the Absence of Supporting Cells to Hair Cells Conversion in Postnatal Mice Cochleae.Frontiers in molecular neuroscience · 2018Article
- Article
- Regeneration of hair cells in the mammalian vestibular system.Frontiers of medicine · 2016Review
- Whole Mount Dissection and Immunofluorescence of the Adult Mouse Cochlea.Journal of visualized experiments : JoVE · 2016Article
- Transcription factor STOX1 regulates proliferation of inner ear epithelial cells via the AKT pathway.Cell proliferation · 2015Article
- How to bury the dead: elimination of apoptotic hair cells from the hearing organ of the mouse.Journal of the Association for Research in Otolaryngology : JARO · 2014Article
- Cisplatin exposure damages resident stem cells of the mammalian inner ear.Developmental dynamics : an official publication of the American Association of Anatomists · 2014Article
- β-Catenin is required for hair-cell differentiation in the cochlea.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014Article
- Responses to cell loss become restricted as the supporting cells in mammalian vestibular organs grow thick junctional actin bands that develop high stability.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014Article
- Inner ear supporting cells: rethinking the silent majority.Seminars in cell & developmental biology · 2013Review
- A historical to present-day account of efforts to answer the question: "what puts the brakes on mammalian hair cell regeneration?".Hearing research · 2013Review
- In vivo proliferative regeneration of balance hair cells in newborn mice.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2012Article
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Mature mammals are uniquely vulnerable to permanent auditory and vestibular deficits, because the cell proliferation that produces replacement hair cells in other vertebrates is limited in mammals. To investigate the cellular mechanisms responsible for that difference, we created excision lesions in the sensory epithelium of embryonic and 2-week-old mouse utricles. Lesions in embryonic utricles closed in <24 h via localized expansion of supporting cells, which then reentered the cell cycle. Pharmacological treatments combined with time-lapse microscopy demonstrated that the healing depended on Rho-mediated contraction of an actin ring at the leading edge of the lesion. In contrast, lesions in utricles from 2-week-old and older mice remained open even after 48 h. Supporting cells in those utricles remained compact and columnar and had significantly stouter cortical actin belts than those in embryonic sensory epithelia. This suggests that cytoskeletal changes may underlie the age-related loss of proliferation in mammalian ears by limiting the capacity for mature supporting cells to change shape. In mature utricles, exogenous stimulation with lysophosphatidic acid overcame this maturational block and induced closure of lesions, promoting supporting cell expansion and subsequent proliferation. After lysophosphatidic acid treatment, 85% of the mature supporting cells that had spread to a planar area >300 microm2 entered S-phase, whereas only 10% of those cells that had a planar area <100 microm2 entered S-phase. Together, these results indicate that cellular shape change can overcome the normal postnatal cessation of supporting cell proliferation that appears to limit regeneration in mammalian vestibular epithelia.
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