Evidence map›Paper›PMID 17442792›Full record

ArticleJournal of clinical microbiology2007

Identification of genotypically diverse Cryptococcus neoformans and Cryptococcus gattii isolates by Luminex xMAP technology.

M Bovers, M R Diaz, F Hagen, L Spanjaard, B Duim, C E Visser, H L Hoogveld, J Scharringa, I M Hoepelman, J W Fell and 1 more

Open access · greenAbstract readEvaluation Study
In one paragraph

Article in Journal of clinical microbiology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
4.1field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 56 citations in OpenAlex.

  1. Rapid and ultrasensitive detection ofFrontiers in cellular and infection microbiology · 2026
    Article
  2. Review
  3. Article
  4. Review
  5. Review
  6. Article
  7. Cryptococcus gattii infections.Clinical microbiology reviews · 2014
    Review
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Evaluation of Pyrosequencing technology for the identification of clinically relevant non-dematiaceous yeasts and related species.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2008
    Article
  17. Review
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 5 institutions in 2 countries.

M BoversCBS-Fungal Biodiversity Centre, Uppsalalaan 8, NL-3584CT Utrecht, The Netherlands.
M R Diaz
F Hagen
L Spanjaard
B Duim
C E Visser
H L Hoogveld
J Scharringa
I M Hoepelman
J W Fell
T Boekhout
Academic Medical Center · NLWesterdijk Fungal Biodiversity Institute · NLUniversity Medical Center Utrecht · NLUniversity of Miami · USNetherlands Institute of Ecology · NL

Funding

High through-put detection of fungal pathogensU01AI053879 · NIAID · UNIVERSITY OF MIAMI ROSENTEIL SCHOOL · PI FELL, JACK W · 2002 to 2004
$1.1M
NIAID NIH HHS 1-U01 AI53879-01NIAID NIH HHS U01 AI053879
6 · The paper itself

Abstract

A Luminex suspension array, which had been developed for identification of Cryptococcus neoformans and Cryptococcus gattii isolates, was tested by genotyping a set of 58 mostly clinical isolates. All genotypes of C. neoformans and C. gattii were included. In addition, cerebrospinal fluid (CSF) obtained from patients with cryptococcal meningitis was used to investigate the feasibility of the technique for identification of the infecting strain. The suspension array correctly identified haploid isolates in all cases. Furthermore, hybrid isolates possessing two alleles of the Luminex probe region could be identified as hybrids. In CSF specimens, the genotype of the cryptococcal strains responsible for infection could be identified after optimization of the PCR conditions. However, further optimization of the DNA extraction protocol is needed to enhance the usability of the method in clinical practice.

Indexed as

Mycological Typing TechniquesAdultAgedCerebrospinal FluidCryptococcosisCryptococcusCryptococcus neoformansDNA, FungalFemaleFlow CytometryGenotypeHumansMaleMeningitis, CryptococcalMicrospheresMiddle AgedDNA, FungalSuspensions

Identifiers

PMID17442792
PMCPMC1933031
OpenAlexW2144901548

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.