ArticleJournal of neurophysiology2007
Action potential timing precision in dorsal cochlear nucleus pyramidal cells.
Article in Journal of neurophysiology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 33 citations in OpenAlex.
- Kv1 channels regulate variations in spike patterning and temporal reliability in the avian cochlear nucleus angularis.Journal of neurophysiology · 2022Article
- Theoretical Relationship Between Two Measures of Spike Synchrony: Correlation Index and Vector Strength.Frontiers in neuroscience · 2021Article
- Sparsely Distributed, Pre-synaptic Kv3 KFrontiers in cellular neuroscience · 2021Article
- Spike threshold adaptation diversifies neuronal operating modes in the auditory brain stem.Journal of neurophysiology · 2019Article
- Classification of neurons in the adult mouse cochlear nucleus: Linear discriminant analysis.PloS one · 2019Article
- Kv3 KNeuropharmacology · 2018Article
- A biophysical modelling platform of the cochlear nucleus and other auditory circuits: From channels to networks.Hearing research · 2018Article
- Heterogeneity of intrinsic biophysical properties among cochlear nucleus neurons improves the population coding of temporal information.Journal of neurophysiology · 2014Article
- Neuronal spike timing adaptation described with a fractional leaky integrate-and-fire model.PLoS computational biology · 2014Article
- A computational study of spike time reliability in two types of threshold dynamics.Journal of mathematical neuroscience · 2013Article
- Intrinsic firing properties in the avian auditory brain stem allow both integration and encoding of temporally modulated noisy inputs in vitro.Journal of neurophysiology · 2012Article
- The effect of neural noise on spike time precision in a detailed CA3 neuron model.Computational and mathematical methods in medicine · 2012Article
- Article
- Difference in response reliability predicted by spectrotemporal tuning in the cochlear nuclei of barn owls.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2011Article
- Somatosensory inputs modify auditory spike timing in dorsal cochlear nucleus principal cells.The European journal of neuroscience · 2011Article
- Molecular layer inhibitory interneurons provide feedforward and lateral inhibition in the dorsal cochlear nucleus.Journal of neurophysiology · 2010Article
- Aged-related loss of temporal processing: altered responses to amplitude modulated tones in rat dorsal cochlear nucleus.Neuroscience · 2008Article
- Article
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Many studies of the dorsal cochlear nucleus (DCN) have focused on the representation of acoustic stimuli in terms of average firing rate. However, recent studies have emphasized the role of spike timing in information encoding. We sought to ascertain whether DCN pyramidal cells might employ similar strategies and to what extent intrinsic excitability regulates spike timing. Gaussian distributed low-pass noise current was injected into pyramidal cells in a brain slice preparation. The shuffled autocorrelation-based analysis was used to compute a correlation index of spike times across trials. The noise causes the cells to fire with temporal precision (SD congruent with 1-2 ms) and high reproducibility. Increasing the coefficient of variation of the noise improved the reproducibility of the spike trains, whereas increasing the firing rate of the neuron decreased the neurons' ability to respond with predictable patterns of spikes. Simulated inhibitory postsynaptic potentials superimposed on the noise stimulus enhanced spike timing for >300 ms, although the enhancement was greatest during the first 100 ms. We also found that populations of pyramidal neurons respond to the same noise stimuli with correlated spike trains, suggesting that ensembles of neurons in the DCN receiving shared input can fire with similar timing. These results support the hypothesis that spike timing can be an important aspect of information coding in the DCN.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.