ArticleJournal of virology2007
Murine gammaherpesvirus 68 contains two functional lytic origins of replication.
Article in Journal of virology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
8 citing papers in PubMed.
- RNA-guided gene editing of the murine gammaherpesvirus 68 genome reduces infectious virus production.PloS one · 2021Article
- Comparative Analysis of Gammaherpesvirus Circular RNA Repertoires: Conserved and Unique Viral Circular RNAs.Journal of virology · 2019Article
- Multiple Lytic Origins of Replication Are Required for Optimal Gammaherpesvirus Fitness In Vitro and In Vivo.PLoS pathogens · 2016Article
- CTCF and Sp1 interact with the Murine gammaherpesvirus 68 internal repeat elements.Virus genes · 2012Article
- Replication and transcription activator (RTA) of murine gammaherpesvirus 68 binds to an RTA-responsive element and activates the expression of ORF18.Journal of virology · 2011Article
- The M10 locus of murine gammaherpesvirus 68 contributes to both the lytic and the latent phases of infection.Journal of virology · 2009Article
- Identification and functional characterization of the left origin of lytic replication of murine gammaherpesvirus 68.Virology · 2009Article
- Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
A 1.25-kbp DNA fragment from the right side of the genome containing the lytic origin of replication (oriLyt) of murine gammaherpesvirus 68 (MHV-68) has been identified by a plasmid replication assay. Here we show that a mutant MHV-68 with a deletion of an essential part of this oriLyt, generated by using an MHV-68 bacterial artificial chromosome, was only slightly attenuated and still able to replicate but that a mutant containing an additional deletion on the left side of the genome was replication deficient. The newly identified region was sufficient to support plasmid replication, thus providing evidence for a second oriLyt.
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Registered trials
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