Evidence map›Paper›PMID 17442457›Full record

ArticleNeurobiology of aging2008

No association of dynamin binding protein (DNMBP) gene SNPs and Alzheimer's disease.

Ryan L Minster, Steven T DeKosky, M Ilyas Kamboh

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neurobiology of aging, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Ryan L MinsterDepartment of Human Genetics, University of Pittsburgh, Pittsburgh, PA 15261, USA.
Steven T DeKosky
M Ilyas Kamboh

Funding

TREATMENT OF DEPRESSION IN ALZHEIMER'S DISEASEP50AG005133 · NIA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI BECKER, JAMES T. · 1985 to 2019
$43.0M
YEAST ER MOLECULAR CHAPERONE TRANSLOCATION: GENOME DATABANK HOMOLOGSP41RR006009 · NCRR · MELLON PITTS CORPORATION (MPC CORP) · PI KNOLL, ERIC · 1990 to 2011
$22.0M
RISK GENES IN ALZHEIMERS DISEASER01AG013672 · NIA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI KAMBOH, M. ILYAS · 1996 to 2006
$1.3M
NCRR NIH HHS P41 RR006009NIA NIH HHS AG05133NIA NIH HHS AG13672NIA NIH HHS P50 AG005133NIA NIH HHS R01 AG013672
6 · The paper itself

Abstract

A recent scan of single nucleotide polymorphisms (SNPs) on chromosome 10q found significant association of six correlated SNPs with late-onset Alzheimer's disease (AD) among Japanese. We examined the SNP with the highest statistical significance (rs3740058) in a large Caucasian American case-control cohort and the remaining five SNPs in a smaller subset of cases and controls. We observed no association of statistical significance in either the total sample or the APOE*4 non-carriers for any of the SNPs.

Indexed as

Alzheimer DiseaseApolipoprotein E4BrainCase-Control StudiesChromosomes, Human, Pair 10Cohort StudiesCytoskeletal ProteinsDNA Mutational AnalysisGene FrequencyGenetic Predisposition to DiseaseGenetic TestingGenotypeHeterozygoteHumansPolymorphism, Single NucleotideWhite PeopleApolipoprotein E4Cytoskeletal ProteinsDNMBP protein, human

Identifiers

PMID17442457
PMCPMC2553275

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.