ArticleTheoretical population biology2007
Damage segregation at fissioning may increase growth rates: a superprocess model.
Article in Theoretical population biology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed.
- Article
- Progressive decline in old pole gene expression signal enhances phenotypic heterogeneity in bacteria.Science advances · 2024Article
- Balance between asymmetric allocation and repair of somatic damage in unicellular life forms as an ancient form of r/K selection.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Unicellular life balances asymmetric allocation and repair of somatic damage representing the origin of r/K selection.bioRxiv : the preprint server for biology · 2023Article
- Asymmetry, division of labour and the evolution of ageing in multicellular organisms.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2021Review
- Senescence in Bacteria and Its Underlying Mechanisms.Frontiers in cell and developmental biology · 2021Review
- Protein aggregates encode epigenetic memory of stressful encounters in individual Escherichia coli cells.PLoS biology · 2018Article
- Intraneuronal protein aggregation as a trigger for inflammation and neurodegeneration in the aging brain.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2017Review
- Aging: progressive decline in fitness due to the rising deleteriome adjusted by genetic, environmental, and stochastic processes.Aging cell · 2016Review
- Asymmetrical Damage Partitioning in Bacteria: A Model for the Evolution of Stochasticity, Determinism, and Genetic Assimilation.PLoS computational biology · 2016Article
- Systematic analysis of asymmetric partitioning of yeast proteome between mother and daughter cells reveals "aging factors" and mechanism of lifespan asymmetry.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
- Asymmetric segregation of damaged cellular components in spatially structured multicellular organisms.PloS one · 2014Article
- Biological consequences and advantages of asymmetric bacterial growth.Annual review of microbiology · 2013Review
- A model for damage load and its implications for the evolution of bacterial aging.PLoS genetics · 2010Article
- Asymmetric segregation of protein aggregates is associated with cellular aging and rejuvenation.Proceedings of the National Academy of Sciences of the United States of America · 2008Article
- On the evolutionary origin of aging.Aging cell · 2007Article
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2 authors.
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Abstract
A fissioning organism may purge unrepairable damage by bequeathing it preferentially to one of its daughters. Using the mathematical formalism of superprocesses, we propose a flexible class of analytically tractable models that allow quite general effects of damage on death rates and splitting rates and similarly general damage segregation mechanisms. We show that, in a suitable regime, the effects of randomness in damage segregation at fissioning are indistinguishable from those of randomness in the mechanism of damage accumulation during the organism's lifetime. Moreover, the optimal population growth is achieved for a particular finite, non-zero level of combined randomness from these two sources. In particular, when damage accumulates deterministically, optimal population growth is achieved by a moderately unequal division of damage between the daughters, while too little or too much division is sub-optimal. Connections are drawn both to recent experimental results on inheritance of damage in protozoans, and to theories of aging and resource division between siblings.
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