ArticleAllergy2007
Codeine induces human mast cell chemokine and cytokine production: involvement of G-protein activation.
Article in Allergy, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 75 citations in OpenAlex.
- Psychiatric, Cardiovascular and Skeletal Risks of Codeine versus Oxycodone in Hip Osteoarthritis: A Population-Based Cohort Study.Drug design, development and therapy · 2026Article
- Clinical Applications of Sunscreens and Formulation Advancements.Current drug research reviews · 2024Review
- UltramicronizedBiomolecules · 2023Article
- Sodium butyrate supresses malignant human mast cell proliferation, downregulates expression of KIT and promotes differentiation.Frontiers in allergy · 2023Article
- Article
- Drugs and Vaccines Hypersensitivity in Children with Mastocytosis.Journal of clinical medicine · 2022Review
- Mas-Related G Protein-Coupled Receptor-X2 and Its Role in Non-immunoglobulin E-Mediated Drug Hypersensitivity.Immunology and allergy clinics of North America · 2022Review
- Article
- MRGPRX2 Is the Codeine Receptor of Human Skin Mast Cells: Desensitization through β-Arrestin and Lack of Correlation with the FcεRI Pathway.The Journal of investigative dermatology · 2021Article
- Review
- A Challenge for Allergologist: Application of Allergy Diagnostic Methods in Mast Cell Disorders.International journal of molecular sciences · 2021Review
- Rapid identification of human mast cell degranulation regulators using functional genomics coupled to high-resolution confocal microscopy.Nature protocols · 2020Article
- Calming the Storm: Natural Immunosuppressants as Adjuvants to Target the Cytokine Storm in COVID-19.Frontiers in pharmacology · 2020Review
- Mast cell mediators: their differential release and the secretory pathways involved.Frontiers in immunology · 2014Review
- A Case of Codeine Induced Anaphylaxis via Oral Route.Allergy, asthma & immunology research · 2014Article
- Accumulation of eosinophils, mast cells, and basophils in the spleen in anaphylactic deaths.Forensic science, medicine, and pathology · 2013Article
- Pain in chronic pancreatitis: managing beyond the pancreatic duct.World journal of gastroenterology · 2013Review
- Allergic manifestations and cutaneous histamine responses in patients with McCune Albright syndrome.The World Allergy Organization journal · 2013Article
- Human mast cells synthesize and release angiogenin, a member of the ribonuclease A (RNase A) superfamily.Journal of leukocyte biology · 2009Article
- Ureteral stones due to systemic mastocytosis: diagnostic and therapeutic characteristics.Urological research · 2009Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
backgroundActivation of mast cells and the systemic release of histamine are common side effects of opiates such as codeine and morphine. In some individuals, codeine not only elicits a sizable early response due to mast cell degranulation, but can also lead to late cutaneous allergic inflammation possibly through the production of chemokines. However, individuals who exhibit a late phase reaction to codeine often do not react to its synthetic analog, meperidine. The goal of this study was to test whether codeine and meperidine induce secretion of inflammatory mediators in human mast cells.
methodsTo characterize opiate activation of human mast cells, we stimulated cultured human (LAD2 cell line and CD34+-derived) mast cells with codeine and meperidine and measured degranulation and chemokine production.
resultsCodeine, but not meperidine, activated human mast cell degranulation within 30 min in a dose-dependent manner. Degranulation was blocked by the phosphoinositol-3 kinase (PI3K) inhibitor, wortmannin, and pertussis toxin but not by Ro-31-8220, a PKC inhibitor or forskolin, a cyclic adenylyl cyclase activator. After 3 and 8 h of stimulation, codeine, but not meperidine, activated human mast cells to release monocyte chemoattractant protein-1 (CCL2), regulated on activation, normal T expressed and secreted (RANTES, CCL5) and interleukin-8 (CXCL 8) but not inducible protein-10 (CXCL10).
conclusionsCodeine activates human mast cell degranulation and chemokine production by activating protein kinase A and PI3 kinase, possibly leading to NF-kappaB activation. Therefore, opiates may regulate late phase allergic inflammation by activating chemokine production by human mast cells.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.