ArticleAllergy2007
House dust (1-3)-beta-D-glucan and wheezing in infants.
Article in Allergy, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
40 citing papers in PubMed, 1 synthesis or guideline pooled it, 108 citations in OpenAlex.
- Residential dampness and molds and the risk of developing asthma: a systematic review and meta-analysis.PloS one · 2012Pooled it
- Indoor microbiome and allergic diseases: From theoretical advances to prevention strategies.Eco-Environment & Health · 2022Review
- Housing conditions and respiratory morbidity in Indigenous children in remote communities in Northwestern Ontario, Canada.CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne · 2022Article
- Quantitative and semiquantitative estimates of mold exposure in infancy and childhood respiratory health.Environmental epidemiology (Philadelphia, Pa.) · 2020Article
- Variability of indoor fungal microbiome of green and non-green low-income homes in Cincinnati, Ohio.The Science of the total environment · 2018Article
- Environmental determinants of allergy and asthma in early life.The Journal of allergy and clinical immunology · 2017Review
- Fungal Exposure and Asthma: IgE and Non-IgE-Mediated Mechanisms.Current allergy and asthma reports · 2016Review
- Pediatric Asthma and the Indoor Microbial Environment.Current environmental health reports · 2016Review
- Cellular and molecular mechanisms of fungal β-(1→6)-glucan in macrophages.Innate immunity · 2015Article
- Exposure to indoor pollutants and Wheeze and asthma development during early childhood.International journal of environmental research and public health · 2015Review
- Early-life mold and tree sensitivity is associated with allergic eosinophilic rhinitis at 4 years of age.Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology · 2015Article
- Asthma and allergy development: contrasting influences of yeasts and other fungal exposures.Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology · 2015Article
- Quantity and diversity of environmental microbial exposure and development of asthma: a birth cohort study.Allergy · 2014Article
- Fungal exposure, atopy, and asthma exacerbations in Puerto Rican children.Annals of the American Thoracic Society · 2014Article
- Exposure to Beta-(1,3)-D-glucan in house dust at age 7-10 is associated with airway hyperresponsiveness and atopic asthma by age 11-14.PloS one · 2014Article
- Early life microbial exposure and fractional exhaled nitric oxide in school-age children: a prospective birth cohort study.Environmental health : a global access science source · 2013Article
- Characterization of the monthly variation in (1 → 3)-β-D-glucan concentrations in university laboratories.Environmental monitoring and assessment · 2013Article
- Article
- Microbial content of household dust associated with exhaled NO in asthmatic children.Environment international · 2013Article
- Dispersal in microbes: fungi in indoor air are dominated by outdoor air and show dispersal limitation at short distances.The ISME journal · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 2 institutions in 1 country.
Funding
Abstract
background(1-3)-Beta-D-glucan is a fungal cell wall component, suspected to cause respiratory symptoms in adults. However, very little is known on the possible health effects of (1-3)-beta-D-glucan during infancy. We examined the association between (1-3)-beta-D-glucan exposure and the prevalence of allergen sensitization and wheezing during the first year of life in a birth cohort of 574 infants born to atopic parents. Endotoxin exposure was included as a possible confounder.
methods(1-3)-Beta-D-glucan and endotoxin exposures were measured in settled dust collected from infants' primary activity rooms. The primary outcomes at approximately age one included parental reports of recurrent wheezing and allergen sensitization evaluated by skin prick testing to a panel of 15 aeroallergens as well as milk and egg white.
resultsExposure to high (1-3)-beta-D-glucan concentration (within fourth quartile) was associated with reduced likelihood of both recurrent wheezing [adjusted OR (aOR) = 0.39, 95% CI = 0.16-0.93] and recurrent wheezing combined with allergen sensitization (aOR = 0.13, 95% CI = 0.03-0.61). Similar trends were found between (1-3)-beta-D-glucan concentrations and allergen sensitization (aOR = 0.57, 95% CI = 0.30-1.10). In contrast, recurrent wheezing with or without allergen sensitization was positively associated with low (1-3)-beta-D-glucan exposure within the first quartile (aOR = 3.04, 95% CI = 1.25-7.38; aOR = 4.89, 95% CI = 1.02-23.57). There were no significant associations between endotoxin exposure and the studied health outcomes.
conclusionsThis is the first study to report that indoor exposure to high levels of (1-3)-beta-D-glucan (concentration >60 microg/g) is associated with decreased risk for recurrent wheezing among infants born to atopic parents. This effect was more pronounced in the subgroup of allergen-sensitized infants.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.