ArticleCanadian journal of public health = Revue canadienne de sante publique
Prevalence and associated factors of hepatitis C infection (HCV) in a multi-site Canadian population of illicit opioid and other drug users (OPICAN).
Article in Canadian journal of public health = Revue canadienne de sante publique. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.
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Who cites it
8 citing papers in PubMed, 1 synthesis or guideline pooled it, 17 citations in OpenAlex.
- Risk of window period hepatitis-C infection in high infectious risk donors: systematic review and meta-analysis.American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons · 2011Pooled it
- Correlates of incarceration among young methamphetamine users in Chiang Mai, Thailand.American journal of public health · 2009Trial
- Add-On Selective Estrogen Receptor Modulators for Methadone Maintenance Treatment.Frontiers in endocrinology · 2021Article
- Associated Factors of Maintenance in Patients under Treatment with Methadone: A Comprehensive Systematic Review and Meta-Analysis.Addiction & health · 2018Review
- Guidance on the use of increased infectious risk donors for organ transplantation.Transplantation · 2014Article
- Sex differences in outcomes of methadone maintenance treatment for opioid addiction: a systematic review protocol.Systematic reviews · 2014Article
- Hepatitis C avoidance in injection drug users: a typology of possible protective practices.PloS one · 2013Article
- Prevalence of HCV risk behaviors among prison inmates: tattooing and injection drug use.Journal of health care for the poor and underserved · 2011Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundHepatitis C virus (HCV) infection is highly prevalent in illicit drug user populations, with three in four new HCV infections related to this risk behaviour and a growing HCV disease burden in Canada. Using data from a multi-site cohort study of illicit opioid users in five Canadian cities (OPICAN), this paper explores the prevalence and predictors of HCV status in this high-risk population.
methodsHCV status of cohort participants was assessed by salivary antibody test. Univariate relationships of HCV status with select variables were examined on the basis of cohort baseline data, and subsequently multivariate models using logistic regression to determine independent predictors of HCV status were generated.
results54.6% of the analysis sample (n=482) was HCV positive. Significant differences in terms of HCV prevalence existed across the sites. Significant variables in the final stepwise logistic regression model included age, site (Toronto), unprotected sex, injecting drug use, drug treatment and incarceration in past year, in addition to opioid use in combination with non-opioids. DISCUSSION: Besides drug injecting, various other socio-behavioural factors were associated with HCV status in our cohort. On this basis, interventions focusing solely on injection risks are overly limited in scope to prevent HCV transmission in the high-risk population of illicit drug users and need to be broadened. Prevention efforts should also target young injectors as a priority.
Indexed as
Identifiers
17441537PMC6975734W1508353359What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.