ReviewHuman brain mapping2007
Neuroimaging endophenotypes: strategies for finding genes influencing brain structure and function.
Review in Human brain mapping, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 143 papers, 6 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
143 citing papers in PubMed, 6 syntheses or guidelines pooled it, 263 citations in OpenAlex.
- A systematic review and meta-analysis of imaging genetics studies of specific reading disorder.Cognitive neuropsychology · 2021Pooled it
- Working Memory in Unaffected Relatives of Patients With Schizophrenia: A Meta-Analysis of Functional Magnetic Resonance Imaging Studies.Schizophrenia bulletin · 2016Pooled it
- Stuttering, induced fluency, and natural fluency: a hierarchical series of activation likelihood estimation meta-analyses.Brain and language · 2014Pooled it
- Genetic and environmental influences on neuroimaging phenotypes: a meta-analytical perspective on twin imaging studies.Twin research and human genetics : the official journal of the International Society for Twin Studies · 2012Pooled it
- Heritability of brain ventricle volume: converging evidence from inconsistent results.Neurobiology of aging · 2012Pooled it
- Imaging genetic liability to schizophrenia: systematic review of FMRI studies of patients' nonpsychotic relatives.Schizophrenia bulletin · 2009Pooled it
- Emotion Processing in Schizophrenia: Insights From a Brain Imaging Study Comparing Patients, Siblings, and Healthy Controls.Human brain mapping · 2026Trial
- Genome-wide association study of emotional empathy in children.Scientific reports · 2020Trial
- Cortical Oscillations as an Endophenotype Mediating ApoE-ε2 Effects on Poststroke Functional Status.Stroke · 2026Article
- EndoPRS: Incorporating endophenotype information to improve polygenic risk scores for clinical endpoints-A study in asthma.American journal of human genetics · 2025Article
- Genetic Vulnerability to Social Anxiety Disorder.Current topics in behavioral neurosciences · 2025Review
- Genetic and environmental influences on structural brain development from childhood to adolescence: A longitudinal twin study on cortical thickness, surface area, and subcortical volume.Developmental cognitive neuroscience · 2024Article
- Neuroanatomical Predictors of Transcranial Direct Current Stimulation (tDCS)-Induced Modifications in Neurocognitive Task Performance in Typically Developing Individuals.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Large-Scale Neuroimaging of Mental Illness.Current topics in behavioral neurosciences · 2024Review
- Structural Relationship between Cerebral Gray and White Matter Alterations in Degenerative Cervical Myelopathy.Tomography (Ann Arbor, Mich.) · 2023Article
- Genome- and Exome-Wide Association Studies Revealed Candidate Genes Associated with DaTscan Imaging Features.Parkinson's disease · 2023Article
- Telomere length and brain imaging phenotypes in UK Biobank.PloS one · 2023Article
- A cross-cohort replicable and heritable latent dimension linking behaviour to multi-featured brain structure.Communications biology · 2022Article
- Mapping the genetic architecture of cortical morphology through neuroimaging: progress and perspectives.Translational psychiatry · 2022Review
- The sexual brain, genes, and cognition: A machine-predicted brain sex score explains individual differences in cognitive intelligence and genetic influence in young children.Human brain mapping · 2022Article
83 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 3 institutions in 1 country.
Funding
Abstract
It is vitally important to identify the genetic determinants of complex brain-related disorders such as autism, dementia, mood disorders, and schizophrenia. However, the search for genes predisposing individuals to these illnesses has been hampered by their genetic and phenotypic complexity and by reliance upon phenomenologically based qualitative diagnostic systems. Neuroimaging endophenotypes are quantitative indicators of brain structure or function that index genetic liability for an illness. These indices will significantly improve gene discovery and help us to understand the functional consequences of specific genes at the level of systems neuroscience. Here, we review the feasibility of using neuroanatomic and neuropsychological measures as endophenotypes for brain-related disorders. Specifically, we examine specific indices of brain structure or function that are genetically influenced and associated with neurological and psychiatric illness. In addition, we review genetic approaches that capitalize on the use of quantitative traits, including those derived from brain images.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.