ReviewThe Canadian journal of cardiology2007
Management of acute severe perioperative failure of cardiac allografts: a single-centre experience with a review of the literature.
Review in The Canadian journal of cardiology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it, 60 citations in OpenAlex.
- Anesthetic protocol for right ventricular dysfunction management in heart transplantation: systematic review, development and validation.BMC anesthesiology · 2021Pooled it
- Recipient plasma metabolomics as a predictor of heart transplant severe primary graft dysfunction.American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons · 2026Article
- Gene expression analysis of primary graft dysfunction in adult heart transplant recipients: A cohort study.JHLT open · 2025Article
- Mechanical Circulatory Support for Right Ventricular Primary Graft Dysfunction After Heart Transplant: A Review.Clinical transplantation · 2025Review
- Severe and Moderate Primary Graft Dysfunction in Adult Heart Recipients.Brazilian journal of cardiovascular surgery · 2023Article
- Primary graft dysfunction after heart transplantation: a thorn amongst the roses.Heart failure reviews · 2019Review
- Salvage of severe primary graft dysfunction following heart transplantation using extracorporeal life support.Proceedings (Baylor University. Medical Center) · 2018Article
- Postoperative Right Ventricular Failure in Cardiac Surgery.Cardiology research · 2016Review
- Incidence, etiology, and outcome of primary graft dysfunction in adult heart transplant recipients: a single-center experience in Japan.Heart and vessels · 2016Article
- Experience of ECMO in primary graft dysfunction after orthotopic heart transplantation.Arquivos brasileiros de cardiologia · 2015Article
- Primary Cardiac Allograft Dysfunction-Validation of a Clinical Definition.Transplantation · 2015Article
- Extracorporeal rescue for early and late graft failure after cardiac transplantation: short result and long-term followup.TheScientificWorldJournal · 2013Article
- Early graft failure after heart transplant: risk factors and implications for improved donor-recipient matching.Interactive cardiovascular and thoracic surgery · 2012Article
- Primary graft failure after heart transplantation.Journal of transplantation · 2011Article
- Extra cellular matrix remodelling after heterotopic rat heart transplantation: gene expression profiling and involvement of ED-A+ fibronectin, alpha-smooth muscle actin and B+ tenascin-C in chronic cardiac allograft rejection.Histochemistry and cell biology · 2010Article
Corrections and comments
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Authors and funding
10 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundEarly graft failure is associated with high mortality and is the main cause of death within the first 30 days after transplantation. The purpose of the present study was to examine the investigators' experience of severe perioperative acute graft failure and to review the literature.
methodsNine of 385 cardiac transplants (2.3%) performed from 1984 through 2005 developed severe perioperative acute graft failure either in the operating room or within 24 h after cardiac transplantation. Four patients had primary graft failure, two had right heart failure secondary to pulmonary hypertension, one had hyperacute rejection, one had accelerated acute rejection and one possibly sustained a particulate coronary embolus intraoperatively.
resultsAll except the two patients who had right heart failure secondary to pulmonary hypertension received mechanical circulatory support. Three patients were supported with total artificial hearts, two patients received a left ventricular assist device, one patient was supported with extracorporeal life support followed by a right ventricular assist device when the left ventricle recovered, and one patient was supported for several hours with cardiopulmonary bypass. Three patients were retransplanted after mechanical circulatory support, but only one survived. Only one of the nine patients (11%) survived; this patient was supported with a total artificial heart followed by retransplantation.
conclusionThe outcome of severe perioperative acute graft failure is very poor. Mechanical circulatory support and retransplantation are not as successful as in other situations. Due to the shortage of donors and poor outcomes, retransplantation for hyperacute rejection is not advisable.
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