Evidence map›Paper›PMID 17440520›Full record

Trial reportEuropean journal of clinical nutrition2008

Lactobacillus acidophilus 74-2 and Bifidobacterium animalis subsp lactis DGCC 420 modulate unspecific cellular immune response in healthy adults.

A Klein, U Friedrich, H Vogelsang, G Jahreis

Registry-linked trialAbstract readRandomized Controlled Trial
PubMed Publisher
In one paragraph

Trial report in European journal of clinical nutrition, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01479543 (Colonization, Safety, Tolerance, and Effects of Three Probiotic Strains on the Immune System of Healthy Adults), which is not on this map. Cited by 44 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
44citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01479543 nacompletednot on this mapstarted 2011, after this paper: background citation

Colonization, Safety, Tolerance, and Effects of Three Probiotic Strains on the Immune System of Healthy Adults

TypeinterventionalSponsorHero Institute for Infant NutritionRan2011 to 2012Enrolled103ConditionsConditions Influencing Health StatusArmsProbiotic CNCM I-4034, Probiotic CNCM I-4035, Probiotic CNCM I-4036, Probiotics CNCM I-4035 and CNCM I-4036, Placebo
3 · Its place in the literature

Who cites it

44 citing papers in PubMed, 3 syntheses or guidelines pooled it.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

A KleinInstitute of Nutrition, Department of Nutritional Physiology, Friedrich Schiller University, Dornburger Strasse 24, Jena, Germany.
U Friedrich
H Vogelsang
G Jahreis

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveIt was determined whether a combination of Lactobacillus acidophilus (L. acidophilus) 74-2 and Bifidobacterium animalis subsp lactis DGCC 420 (B. lactis 420) affect the faecal microbiota as well as immunological parameters and blood lipids in healthy adults.

designA placebo-controlled, double-blinded, randomized crossover trial was conducted. SUBJECTS: Twenty-six healthy volunteers (mean age 25 years) were recruited by advertising in academical buildings. All of them completed the study.

methodsAfter 3-week run-in period, half of the volunteers consumed 300 g/day of yoghurt supplement containing probiotic strains L. acidophilus 74-2 and B. lactis 420, and the other half received the placebo product for a period of 5 weeks. The two groups were crossed during the following 5-week period. Blood and faecal samples were collected at the end of each period. The faecal content of probiotic bacteria, faecal short-chain fatty acids (SCFA), serum lipids and plasma immune system biomarkers were evaluated.

resultsFaecal proportions of L. acidophilus and of B. lactis increased significantly from 0.02 to 0.19 and 0.4 to 1.4% (P<0.05), respectively. Percentages of granulocytes and monocytes showing phagocytic activity were significantly elevated from 92 to 95% during probiotic intervention, whereas their oxidative burst activity and specific immune parameters remained unaffected. Fecal SCFA and serum cholesterol levels were not influenced by the probiotics. However, serum concentrations of triacylglyceroles decreased significantly by 11.6% (P<0.05) in the probiotic supplementation period.

conclusionsL. acidophilus and B. lactis were recovered in faeces in significantly elevated numbers after supplementation. They are able to modulate unspecific cellular immune response indicated by the increased phagocytic activity.

Indexed as

AdultBifidobacteriumCholesterolColony Count, MicrobialCross-Over StudiesDouble-Blind MethodFatty Acids, VolatileFecesFemaleHumansImmunity, CellularLactobacillus acidophilusLipidsMaleProbioticsTriglyceridesCholesterolFatty Acids, VolatileLipidsTriglycerides

Identifiers

PMID17440520

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.