ArticleMolecular psychiatry2007
The discoidin domain receptor 1 as a novel susceptibility gene for schizophrenia.
Article in Molecular psychiatry, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 2 of them syntheses that pooled it.
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Who cites it
26 citing papers in PubMed, 2 syntheses or guidelines pooled it, 52 citations in OpenAlex.
- Meta-analysis of genome-wide SNP- and pathway-based associations for facets of neuroticism.Journal of human genetics · 2017Pooled it
- Meta-analysis of sex differences in gene expression in schizophrenia.BMC systems biology · 2016Pooled it
- A dual context-aware basecaller for nanopore direct RNA sequencing.Nature communications · 2026Article
- Dysregulation of myelination-related genes in schizophrenia.Journal of neurochemistry · 2024Review
- Associations of altered leukocyte DDR1 promoter methylation and childhood trauma with bipolar disorder and suicidal behavior in euthymic patients.Molecular psychiatry · 2024Article
- Processing speed mediates the relationship between DDR1 and psychosocial functioning in euthymic patients with bipolar disorder presenting psychotic symptoms.Molecular psychiatry · 2024Article
- Coexpression network analysis of the adult brain sheds light on the pathogenic mechanism of DDR1 in schizophrenia and bipolar disorder.Translational psychiatry · 2024Article
- DDR1 and Its Ligand, Collagen IV, Are Involved in In Vitro Oligodendrocyte Maturation.International journal of molecular sciences · 2023Article
- Integration of Transcriptome and Exome Genotyping Identifies Significant Variants with Autism Spectrum Disorder.Pharmaceuticals (Basel, Switzerland) · 2022Article
- Coexpression of the discoidin domain receptor 1 gene with oligodendrocyte-related and schizophrenia risk genes in the developing and adult human brain.Brain and behavior · 2021Article
- Improved haplotype inference by exploiting long-range linking and allelic imbalance in RNA-seq datasets.Nature communications · 2020Article
- Molecular linkage between post-traumatic stress disorder and cognitive impairment: a targeted proteomics study of World Trade Center responders.Translational psychiatry · 2020Article
- An Analysis of Cellular Communication Network Factor Proteins as Candidate Mediators of Postpartum Psychosis Risk.Frontiers in psychiatry · 2019Article
- Do Defective Immune System-Mediated Myelination Processes Increase Postpartum Psychosis Risk?Trends in molecular medicine · 2018Review
- Understanding the pathophysiology of postpartum psychosis: Challenges and new approaches.World journal of psychiatry · 2017Review
- Association between mitochondrial DNA variations and schizophrenia in the northern Chinese Han population.PloS one · 2017Article
- Association of DNA Methylation Differences With Schizophrenia in an Epigenome-Wide Association Study.JAMA psychiatry · 2016Article
- Associations between DNA methylation and schizophrenia-related intermediate phenotypes - a gene set enrichment analysis.Progress in neuro-psychopharmacology & biological psychiatry · 2015Article
- Transcriptome sequencing and genome-wide association analyses reveal lysosomal function and actin cytoskeleton remodeling in schizophrenia and bipolar disorder.Molecular psychiatry · 2015Article
- Genome-wide association study combined with biological context can reveal more disease-related SNPs altering microRNA target seed sites.BMC genomics · 2014Article
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Evidence suggests that myelin alterations could predispose to schizophrenia. Reduced expression of several myelin genes has been observed in schizophrenia patients. Recently, we identified the discoidin domain receptor 1 (DDR1; located at human chromosome 6p21.3) as a myelin gene in the mouse model and in a human oligodendroglial cell line. In the present study we screened for single nucleotide polymorphisms (SNPs) in the DNA from 100 schizophrenia patients. We identified a novel mutation within exon 10 that produces the amino-acid substitution N502S in the a-d isoforms, and M475V in the e isoform. However the frequency of the mutation (2%) was similar in schizophrenia patients and in control subjects. In a case-control assessment with 389 schizophrenic patients and 615 controls, we identified one SNP (SNP9, rs1049623) associated with schizophrenia (odds ratio=1.44, 95% confidence interval: 1.15-1.79, adjusted P=0.0016). This association was confirmed in haplotype analysis; the SNPs 9-10-11 (rs1049623, rs2267641 and rs2239518) haplotype remaining significant even after adjustment for multiple testing (adjusted P=0.0136). Of note was a strong gender dependence in the association, that is, statistical significance restricted to men (adjusted P-value=0.0002). Regression analysis of DDR1 mRNA expression in peripheral blood lymphocytes from schizophrenia patients showed that the presence of the G allele significantly decreased the relative number of mRNA copies in a dose-dependent manner (P=0.003). These data suggest that the risk haplotype tags a cis-acting variant involved in the transcription regulation system of the gene. In conclusion, we propose the DDR1 as a new susceptibility gene for schizophrenia.
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