ArticlePlastic and reconstructive surgery2007
Contractile properties of single permeabilized muscle fibers from congenital cleft palates and normal palates of Spanish goats.
Article in Plastic and reconstructive surgery, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
6 citing papers in PubMed, 13 citations in OpenAlex.
- A new congenital cleft palate New Zealand rabbit model for surgical research.Scientific reports · 2021Article
- Regulatory Mechanisms of Soft Palate Development and Malformations.Journal of dental research · 2019Review
- Isolation and Characterization of Satellite Cells from Rat Head Branchiomeric Muscles.Journal of visualized experiments : JoVE · 2015Article
- Strategies to improve regeneration of the soft palate muscles after cleft palate repair.Tissue engineering. Part B, Reviews · 2012Review
- Effect of cleft palate repair on the susceptibility to contraction-induced injury of single permeabilized muscle fibers from congenitally-clefted goat palates.The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association · 2008Article
- Contraction-induced injury to single permeabilized muscle fibers from normal and congenitally-clefted goat palates.The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association · 2007Article
Corrections and comments
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Authors and funding
9 authors at 5 institutions in 1 country.
Funding
Abstract
backgroundAnalysis of the composition of muscle fibers constituent to a cleft palate could provide significant insight into the cause of velopharyngeal inadequacy. The authors hypothesized that levator veli palatini muscle dysfunction inherent to cleft palates could affect the timing and outcome of cleft palate repair.
methodsSingle, permeabilized muscle fibers from levator veli palatini muscles of three normal (n = 19 fibers) and three chemically induced congenital cleft palates (n = 21 fibers) of 14-month-old goats were isolated, and contractile properties were evaluated. The maximum isometric force and rate constants of tension redevelopment (ktr) were measured, and the specific force and normalized power were calculated for each fiber.
resultsThe ktr measures indicate that cleft fibers are predominantly fast-fatigable; normal fibers are slow fatigue-resistant: after a 10-minute isometric contraction, fibers from cleft palates had a loss of force 16 percent greater than that from normal palates (p = 0.0001). The cross-sectional areas of the fibers from cleft palates (2750 +/- 209 microm2) were greater (p = 0.05) than those from normal palates (2226 +/- 143 microm2). Specific forces did not differ between the two groups. Maximum normalized power of fibers from cleft palates (11.05 +/- 1.82 W/l) was greater (p = 0.0001) than fibers from normal palates (1.60 +/- 0.12 W/l).
conclusionsThere are clear physiologic differences in single muscle fibers from cleft palates and normal palates: cleft palate fibers are physiologically fast, have greater fatigability, and have greater power production. Detection of functional and/or fiber type differences in muscles of cleft palates may provide preoperative identification of a patient's susceptibility to velopharyngeal inadequacy and permit early surgical intervention to correct this clinical condition.
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