ArticleNucleic acids research2007
Sequence analysis of p53 response-elements suggests multiple binding modes of the p53 tetramer to DNA targets.
Article in Nucleic acids research, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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Who cites it
30 citing papers in PubMed, 54 citations in OpenAlex.
- Article
- Zinc cluster transcription factors frequently activate target genes using a non-canonical half-site binding mode.Nucleic acids research · 2023Article
- OIP5-AS1 specifies p53-driven POX transcription regulated by TRPC6 in glioma.Journal of molecular cell biology · 2021Article
- Genomic Space ofInternational journal of molecular sciences · 2021Article
- SUPPRESSOR OF GAMMA RESPONSE 1 acts as a regulator coordinating crosstalk between DNA damage response and immune response in Arabidopsis thaliana.Plant molecular biology · 2020Article
- Review
- The Rich World of p53 DNA Binding Targets: The Role of DNA Structure.International journal of molecular sciences · 2019Review
- Article
- Conformational stability and dynamics of the cancer-associated isoform Δ133p53β are modulated by p53 peptides and p53-specific DNA.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2019Article
- p53 positively regulates the expression of cancer stem cell marker CD133 in HCT116 colon cancer cells.Oncology letters · 2018Article
- Identification of two p53 isoforms from Litopenaeus vannamei and their interaction with NF-κB to induce distinct immune response.Scientific reports · 2017Article
- Article
- Recognition of Local DNA Structures by p53 Protein.International journal of molecular sciences · 2017Review
- Whole-genome cartography of p53 response elements ranked on transactivation potential.BMC genomics · 2015Article
- Identification of two novel functional p53 responsive elements in the herpes simplex virus-1 genome.Virology · 2014Article
- Mapping the p53 transcriptome universe using p53 natural polymorphs.Cell death and differentiation · 2014Article
- Sequence-dependent sliding kinetics of p53.Proceedings of the National Academy of Sciences of the United States of America · 2012Article
- Electron microscopy studies on the quaternary structure of p53 reveal different binding modes for p53 tetramers in complex with DNA.Proceedings of the National Academy of Sciences of the United States of America · 2011Article
- Human single-nucleotide polymorphisms alter p53 sequence-specific binding at gene regulatory elements.Nucleic acids research · 2011Article
- Life or death: p53-induced apoptosis requires DNA binding cooperativity.Cell cycle (Georgetown, Tex.) · 2010Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
Abstract
The p53 tetramer recognizes specifically a 20-bp DNA element. Here, we examined symmetries encoded in p53 response elements (p53REs). We analyzed base inversion correlations within the half-site, as well as in the full-site palindrome. We found that p53REs are not only direct repeats of half-sites; rather, two p53 half-sites couple to form a higher order 20 bp palindrome. The palindrome couplings between the half-sites are stronger for the human than for the mouse genome. The full-site palindrome and half-site palindrome are controlled by insertions between the two half-sites. The most notable feature is that the full-site palindrome with coupling between quarter-sites one and four (H14 coupling) dominates the p53REs without insertions. The most frequently observed insertion in human p53REs of 3 bp enhances the half-site palindrome. The statistical frequencies of the coupling between the half-sites in the human genome correlate with grouped experimental p53 affinities with p53REs. Examination of known p53REs indicates the H14 couplings are stronger for positive regulation than for negatively regulated p53REs, with repressors having the lowest H14 couplings. We propose that the palindromic sequence couplings may encode such potential preferred multiple binding modes of the p53 tetramer to DNA.
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