ArticleNucleic acids research2007
DNA modification by sulfur: analysis of the sequence recognition specificity surrounding the modification sites.
Article in Nucleic acids research, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
28 citing papers in PubMed, 58 citations in OpenAlex.
- Domain classification of archaeal proteomes reveals conserved fold repertoire.PLoS computational biology · 2026Article
- A novel putative genus phage CW39: implications for CRISPR-Cas9-based phage resistance inFrontiers in microbiology · 2026Article
- Biology of host-dependent restriction-modification in prokaryotes.EcoSal Plus · 2025Review
- Comparative pan-genomic analysis reveals pathogenic mechanisms and genomic plasticity inFrontiers in cellular and infection microbiology · 2025Article
- Origin of iodine preferential attack at sulfur in phosphorothioate and subsequent P-O or P-S bond dissociation.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Hypermodified DNA in Viruses of E. coli and Salmonella.EcoSal Plus · 2021Review
- Protein Domain Guided Screen for Sequence Specific and Phosphorothioate-Dependent Restriction Endonucleases.Frontiers in microbiology · 2020Article
- Phosphorothioated DNA Is Shielded from Oxidative Damage.Applied and environmental microbiology · 2019Article
- DNA phosphorothioate modification-a new multi-functional epigenetic system in bacteria.FEMS microbiology reviews · 2019Review
- Structural basis for the recognition of sulfur in phosphorothioated DNA.Nature communications · 2018Article
- Regulation ofFrontiers in microbiology · 2018Article
- Novel genomic island modifies DNA with 7-deazaguanine derivatives.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
- DNA Phosphorothioate Modification Plays a Role in Peroxides Resistance in Streptomyces lividans.Frontiers in microbiology · 2016Article
- Phylogenomics and sequence-structure-function relationships in the GmrSD family of Type IV restriction enzymes.BMC bioinformatics · 2015Article
- Regulation of DNA phosphorothioate modification in Salmonella enterica by DndB.Scientific reports · 2015Article
- Crystallization and preliminary X-ray analysis of the type IV restriction endonuclease ScoMcrA from Streptomyces coelicolor, which cleaves both Dcm-methylated DNA and phosphorothioated DNA.Acta crystallographica. Section F, Structural biology communications · 2015Article
- Computational identification of novel biochemical systems involved in oxidation, glycosylation and other complex modifications of bases in DNA.Nucleic acids research · 2013Article
- Comparative genomics of defense systems in archaea and bacteria.Nucleic acids research · 2013Review
- Live virus-free or die: coupling of antivirus immunity and programmed suicide or dormancy in prokaryotes.Biology direct · 2012Article
- Phosphorothioate DNA as an antioxidant in bacteria.Nucleic acids research · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The Dnd (DNA degradation) phenotype, reflecting a novel DNA modification by sulfur in Streptomyces lividans 1326, was strongly aggravated when one (dndB) of the five genes (dndABCDE) controlling it was mutated. Electrophoretic banding patterns of a plasmid (pHZ209), reflecting DNA degradation, displayed a clear change from a preferential modification site in strain 1326 to more random modifications in the mutant. Fourteen randomly modifiable sites on pHZ209 were localized, and each seemed to be able to be modified only once. Residues in a region (5'-c-cGGCCgccg-3') including a highly conserved 4-bp central core (5'-GGCC-3') in a well-documented preferential modification site were assessed for their necessity by site-directed mutagenesis. While the central core (GGCC) was found to be stringently required in 1326 and in the mutant, 'gccg' flanking its right could either abolish or reduce the modification frequency only in the mutant, and two separate nucleotides to the left had no dramatic effect. The lack of essentiality of DndB for S-modification suggests that it might only be required for enhancing or stabilizing the activity of a protein complex at the required preferential modification site, or resolving secondary structures flanking the modifiable site(s), known to constitute an obstacle for efficient modification.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.