ArticleProceedings of the National Academy of Sciences of the United States of America2007
The same genomic region conditions clonal deletion and clonal deviation to the CD8alphaalpha and regulatory T cell lineages in NOD versus C57BL/6 mice.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 18 citations in OpenAlex.
- CD8ααSkin health and disease · 2021Article
- Distinct PLZFJournal of immunology (Baltimore, Md. : 1950) · 2019Article
- Alloactivation of Naïve CD4Frontiers in immunology · 2019Article
- Extensive Homeostatic T Cell Phenotypic Variation within the Collaborative Cross.Cell reports · 2017Article
- Foxp3 expression in T regulatory cells and other cell lineages.Cancer immunology, immunotherapy : CII · 2014Review
- Thymic negative selection is functional in NOD mice.The Journal of experimental medicine · 2012Article
- In situ differentiation of CD8αα Τ cells from CD4 T cells in peripheral lymphoid tissues.Scientific reports · 2012Article
- A self-reactive TCR drives the development of Foxp3+ regulatory T cells that prevent autoimmune disease.Journal of immunology (Baltimore, Md. : 1950) · 2011Article
- Lineage divergence at the first TCR-dependent checkpoint: preferential γδ and impaired αβ T cell development in nonobese diabetic mice.Journal of immunology (Baltimore, Md. : 1950) · 2011Article
- The defect in T-cell regulation in NOD mice is an effect on the T-cell effectors.Proceedings of the National Academy of Sciences of the United States of America · 2008Article
- Review
- Enhanced thymic selection of FoxP3+ regulatory T cells in the NOD mouse model of autoimmune diabetes.Proceedings of the National Academy of Sciences of the United States of America · 2007Article
- TCR-based lineage tracing: no evidence for conversion of conventional into regulatory T cells in response to a natural self-antigen in pancreatic islets.The Journal of experimental medicine · 2007Article
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
Abstract
Clonal deviation is a mechanism by which immature thymocytes expressing a self-reactive T cell antigen receptor (TCR) are rescued from clonal deletion by adopting an alternative differentiation pathway resistant to apoptosis. Here, we confirm and generalize previous indications that genetic alleles in NOD mice condition ineffective clonal deviation toward the CD8alphaalpha lineage, a peculiar population of TCRalphabeta lymphocytes that electively colonizes the intraepithelial lymphocyte pool in the gut. Thymic selection of CD8alphaalpha cells was very age-dependent, occurring almost exclusively in the postnatal period. Fewer CD8alphaalpha cells were found in the thymus and intraepithelial lymphocytes of BDC2.5 TCR transgenic mice on the NOD than on the C57BL/6 (B6) background; this paucity extended to standard NOD mice, albeit to a lesser extent. CD8alphaalpha cells resided in the BDC2.5 pancreatic infiltrate, and they were more abundant on the B6 than the NOD background, correlating with aggressivity of the lesion. A (B6(g7) x NOD)F(2) intercross in agonist-challenged BDC2.5 fetal thymic organ cultures demonstrated the existence of a major quantitative trait locus on chromosome 3, coincident with an interval associated with resistance to clonal deletion. A replicate linkage confirmed these positions and showed that the same region also controls clonal deviation toward the CD4(+)FoxP3(+) regulatory T cell lineage. That clonal deviation toward the CD8alphaalpha and regulatory T cell pathways share genetic control further highlights the similarities between these two "rescue lineages," consistent with an immunoregulatory role for CD8alphaalpha cells.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.