ArticleProceedings of the National Academy of Sciences of the United States of America2007
Borrelia burgdorferi intercepts host hormonal signals to regulate expression of outer surface protein A.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 46 citations in OpenAlex.
- Monovalent and multivalent OspA mRNA-LNP vaccines elicit functional antibodies and protect against Borrelia burgdorferi in mice.NPJ vaccines · 2026Article
- Dissection of amino acid acquisition pathways demonstrates that amino acid starvation of Borrelia burgdorferi results in a (p)ppGpp-independent maladaptive response.Communications biology · 2025Article
- Article
- Plasticity in early immune evasion strategies of a bacterial pathogen.Proceedings of the National Academy of Sciences of the United States of America · 2018Article
- Catecholamine-Modulated Novel Surface-Exposed Adhesin LIC20035 of Leptospira spp. Binds Host Extracellular Matrix Components and Is Recognized by the Host during Infection.Applied and environmental microbiology · 2018Article
- Toll-like receptor cascade and gene polymorphism in host-pathogen interaction in Lyme disease.Journal of inflammation research · 2016Review
- Co-feeding transmission in Lyme disease pathogens.Parasitology · 2015Review
- Identification of a core sequence for the binding of BosR to the rpoS promoter region in Borrelia burgdorferi.Microbiology (Reading, England) · 2014Article
- Synthesis of RpoS is dependent on a putative enhancer binding protein Rrp2 in Borrelia burgdorferi.PloS one · 2014Article
- Tick-specific borrelial antigens appear to be upregulated in American but not European patients with Lyme arthritis, a late manifestation of Lyme borreliosis.The Journal of infectious diseases · 2013Article
- Communication between Bacteria and Their Hosts.Scientifica · 2013Review
- Involvement of multiple distinct Bordetella receptor proteins in the utilization of iron liberated from transferrin by host catecholamine stress hormones.Molecular microbiology · 2012Article
- Of ticks, mice and men: understanding the dual-host lifestyle of Lyme disease spirochaetes.Nature reviews. Microbiology · 2012Review
- The hybrid histidine kinase Hk1 is part of a two-component system that is essential for survival of Borrelia burgdorferi in feeding Ixodes scapularis ticks.Infection and immunity · 2011Article
- Evidence for D1 dopamine receptor activation by a paracrine signal of dopamine in tick salivary glands.PloS one · 2011Article
- Article
- Antimicrobial anxiety: the impact of stress on antimicrobial immunity.Journal of leukocyte biology · 2010Review
- Genome-wide transposon mutagenesis identifies a role for host neuroendocrine stress hormones in regulating the expression of virulence genes in Salmonella.Journal of bacteriology · 2010Article
- Norepinephrine mediates acquisition of transferrin-iron in Bordetella bronchiseptica.Journal of bacteriology · 2008Article
- Inter-kingdom signalling: communication between bacteria and their hosts.Nature reviews. Microbiology · 2008Review
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
The Borrelia burgdorferi infectious cycle requires that the organism adapt to vast differences in environmental conditions found in its tick and mammalian hosts. Previous studies have shown that B. burgdorferi accomplishes this accommodation in part by regulating expression of its surface proteins. Outer surface protein A (OspA) is a borrelial protein important in colonization of the tick midgut. OspA is up-regulated when the organism is in its tick host and down-regulated when it is in a mammalian host. However, little is known about how it is up-regulated again in a mammalian host in preparation for entry into a feeding tick. Here, we report that the host neuroendocrine stress hormones, epinephrine and norepinephrine, are specifically bound by B. burgdorferi and result in increased expression of OspA. This recognition is specific and blocked by competitive inhibitors of human adrenergic receptors. To determine whether recognition of catecholamines, which are likely to be present at the site of a tick bite, may play a role in preparing the organism for reentry into a tick from a mammalian host, we administered a beta-adrenergic blocker, propranolol, to infected mice. Propranolol significantly reduced uptake of B. burgdorferi by feeding ticks and decreased expression of OspA in B. burgdorferi recovered from ticks that fed on propranolol-treated mice. Our studies suggest that B. burgdorferi may co-opt host neuroendocrine signals to inform the organism of local changes that predict the presence of its next host and allow it to prepare for transition to a new environment.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.