ArticleMolecular and cellular biology2007
Microphthalmia transcription factor isoforms in mast cells and the heart.
Article in Molecular and cellular biology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 26 citations in OpenAlex.
- Review
- CREB Is Activated by the SCF/KIT Axis in a Partially ERK-Dependent Manner and Orchestrates Survival and the Induction of Immediate Early Genes in Human Skin Mast Cells.International journal of molecular sciences · 2023Article
- The underestimated role of the microphthalmia-associated transcription factor (MiTF) in normal and pathological haematopoiesis.Cell & bioscience · 2021Review
- Transcription Factors in the Development and Pro-Allergic Function of Mast Cells.Frontiers in allergy · 2021Review
- MITF interacts with the SWI/SNF subunit, BRG1, to promote GATA4 expression in cardiac hypertrophy.Journal of molecular and cellular cardiology · 2015Article
- FHL2 switches MITF from activator to repressor of Erbin expression during cardiac hypertrophy.International journal of cardiology · 2015Article
- Integrated microRNA-mRNA analysis of coronary artery disease.Molecular biology reports · 2014Article
- Cardiac hypertrophy is negatively regulated by miR-541.Cell death & disease · 2014Article
- A transcriptional network underlies susceptibility to kidney disease progression.EMBO molecular medicine · 2012Article
- Genetic and functional evaluation of MITF as a candidate gene for cutaneous melanoma predisposition in pigs.Mammalian genome : official journal of the International Mammalian Genome Society · 2011Article
- A novel isoform of microphthalmia-associated transcription factor inhibits IL-8 gene expression in human cervical stromal cells.Molecular endocrinology (Baltimore, Md.) · 2010Article
- Zeb1 represses Mitf and regulates pigment synthesis, cell proliferation, and epithelial morphology.Investigative ophthalmology & visual science · 2009Article
- Diadenosine tetraphosphate hydrolase is part of the transcriptional regulation network in immunologically activated mast cells.Molecular and cellular biology · 2008Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The microphthalmia transcription factor (Mitf) is critical for the survival and differentiation of a variety of cell types. While on the transcript level it has been noted that melanocytes and cardiomyocytes express specific Mitf isoforms, mast cells express several isoforms, mainly Mitf-H and Mitf-MC, whose function has not been thoroughly investigated. We found that in mast cells the expression of the specific Mitf isoforms is dependent on physiological stimuli that cause a major shifting of promoter usage and internal splicing. For example, activation of the c-kit signaling pathway almost totally abolished one of the main splice isoforms. Since cardiomyocytes express only the Mitf-H isoform, they were an ideal system to determine this isoform's physiological role. We identified that the expression of myosin light-chain 1a (MLC-1a) is regulated by Mitf-H. Interestingly, the transactivation of MLC-1a by Mitf-H in cardiomyocytes is decreased by overexpression of the splice form with exon 6a. In conclusion, we found that there is physiological switching of Mitf isoforms and that the promoter context and the cell context have a combined influence on gene expression programs.
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