ArticleThe Journal of general physiology2007
Probing the cavity of the slow inactivated conformation of shaker potassium channels.
Article in The Journal of general physiology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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Who cites it
31 citing papers in PubMed, 43 citations in OpenAlex.
- Closed state structure of the pore revealed by uncoupled Shaker KNature communications · 2025Article
- Isoleucine gate blocks KeLife · 2024Article
- Ion occupancy of the selectivity filter controls opening of a cytoplasmic gate in the KNature communications · 2024Article
- Molecular rearrangements in S6 during slow inactivation in Shaker-IR potassium channels.The Journal of general physiology · 2023Article
- Mechanisms Underlying C-type Inactivation in Kv Channels: Lessons From Structures of Human Kv1.3 and Fly Shaker-IR Channels.Frontiers in pharmacology · 2022Review
- Shaker-IR K+ channel gating in heavy water: Role of structural water molecules in inactivation.The Journal of general physiology · 2021Article
- The activation gate controls steady-state inactivation and recovery from inactivation in Shaker.The Journal of general physiology · 2020Article
- Lipid-protein interactions modulate the conformational equilibrium of a potassium channel.Nature communications · 2020Article
- Article
- Closed-state inactivation involving an internal gate in Kv4.1 channels modulates pore blockade by intracellular quaternary ammonium ions.Scientific reports · 2016Article
- Allosteric coupling of the inner activation gate to the outer pore of a potassium channel.Scientific reports · 2013Article
- Importance of lipid-pore loop interface for potassium channel structure and function.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- The voltage-dependent gate in MthK potassium channels is located at the selectivity filter.Nature structural & molecular biology · 2013Article
- Verapamil- and state-dependent effect of 2-aminoethylmethanethiosulphonate (MTSEA) on hK(v)1.3 channels.British journal of pharmacology · 2012Article
- Modeling-independent elucidation of inactivation pathways in recombinant and native A-type Kv channels.The Journal of general physiology · 2012Article
- Interaction of the S6 proline hinge with N-type and C-type inactivation in Kv1.4 channels.Biophysical journal · 2012Article
- Gating transitions in the selectivity filter region of a sodium channel are coupled to the domain IV voltage sensor.Proceedings of the National Academy of Sciences of the United States of America · 2012Article
- Voltage gated ion channel function: gating, conduction, and the role of water and protons.International journal of molecular sciences · 2012Review
- Multiple modalities converge on a common gate to control K2P channel function.The EMBO journal · 2011Article
- Molecular basis for class Ib anti-arrhythmic inhibition of cardiac sodium channels.Nature communications · 2011Article
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 2 countries.
Funding
Abstract
Slow inactivation involves a local rearrangement of the outer mouth of voltage-gated potassium channels, but nothing is known regarding rearrangements in the cavity between the activation gate and the selectivity filter. We now report that the cavity undergoes a conformational change in the slow-inactivated state. This change is manifest as altered accessibility of residues facing the aqueous cavity and as a marked decrease in the affinity of tetraethylammonium for its internal binding site. These findings have implications for global alterations of the channel during slow inactivation and putative coupling between activation and slow-inactivation gates.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.