ArticleThe Journal of cell biology2007
A signal from inside the peroxisome initiates its division by promoting the remodeling of the peroxisomal membrane.
Article in The Journal of cell biology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
What it found
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Who cites it
35 citing papers in PubMed, 72 citations in OpenAlex.
- Molecular mechanisms of mitochondrial dynamics.Nature reviews. Molecular cell biology · 2025Review
- Antiviral Mx proteins have an ancient origin and widespread distribution among eukaryotes.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Antiviral Mx proteins have an ancient origin and widespread distribution among eukaryotes.bioRxiv : the preprint server for biology · 2024Article
- Peroxisomal β-oxidation enzyme, DECR2, regulates lipid metabolism and promotes treatment resistance in advanced prostate cancer.British journal of cancer · 2024Article
- Diacylglycerol metabolism and homeostasis in fungal physiology.FEMS yeast research · 2024Review
- Convergent and divergent mechanisms of peroxisomal and mitochondrial division.The Journal of cell biology · 2023Article
- The ASH1-PEX16 regulatory pathway controls peroxisome biogenesis for appressorium-mediated insect infection by a fungal pathogen.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Determinants of Peroxisome Membrane Dynamics.Frontiers in physiology · 2022Review
- Peroxisome biogenesis, membrane contact sites, and quality control.EMBO reports · 2019Review
- The metabolism and genetic regulation of lipids in the oleaginous yeast Yarrowia lipolytica.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2019Review
- Geometric instability catalyzes mitochondrial fission.Molecular biology of the cell · 2019Article
- A New Yeast Peroxin, Pex36, a Functional Homolog of Mammalian PEX16, Functions in the ER-to-Peroxisome Traffic of Peroxisomal Membrane Proteins.Journal of molecular biology · 2017Article
- Peroxisomes protect lymphoma cells from HDAC inhibitor-mediated apoptosis.Cell death and differentiation · 2017Article
- Human Peroxin PEX3 Is Co-translationally Integrated into the ER and Exits the ER in Budding Vesicles.Traffic (Copenhagen, Denmark) · 2016Article
- Role of mitochondrial lipids in guiding fission and fusion.Journal of molecular medicine (Berlin, Germany) · 2015Review
- Plant mitochondrial dynamics and the role of membrane lipids.Plant signaling & behavior · 2015Review
- Dynamin-related protein 1 (Drp1) promotes structural intermediates of membrane division.The Journal of biological chemistry · 2014Article
- A dimeric equilibrium intermediate nucleates Drp1 reassembly on mitochondrial membranes for fission.Molecular biology of the cell · 2014Article
- Macromitophagy, neutral lipids synthesis, and peroxisomal fatty acid oxidation protect yeast from "liponecrosis", a previously unknown form of programmed cell death.Cell cycle (Georgetown, Tex.) · 2014Article
- Peroxisomes take shape.Nature reviews. Molecular cell biology · 2013Review
Corrections and comments
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Authors and funding
13 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We define the dynamics of spatial and temporal reorganization of the team of proteins and lipids serving peroxisome division. The peroxisome becomes competent for division only after it acquires the complete set of matrix proteins involved in lipid metabolism. Overloading the peroxisome with matrix proteins promotes the relocation of acyl-CoA oxidase (Aox), an enzyme of fatty acid beta-oxidation, from the matrix to the membrane. The binding of Aox to Pex16p, a membrane-associated peroxin required for peroxisome biogenesis, initiates the biosynthesis of phosphatidic acid and diacylglycerol (DAG) in the membrane. The formation of these two lipids and the subsequent transbilayer movement of DAG initiate the assembly of a complex between the peroxins Pex10p and Pex19p, the dynamin-like GTPase Vps1p, and several actin cytoskeletal proteins on the peroxisomal surface. This protein team promotes membrane fission, thereby executing the terminal step of peroxisome division.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.