ArticleThe Journal of cell biology2007
Three-dimensional structures of the flagellar dynein-microtubule complex by cryoelectron microscopy.
Article in The Journal of cell biology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
What it found
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Who cites it
26 citing papers in PubMed, 66 citations in OpenAlex.
- Review
- IC2 participates in the cooperative activation of outer arm dynein densely attached to microtubules.Cell structure and function · 2023Article
- Article
- Updates on Aptamer Research.International journal of molecular sciences · 2019Review
- Microtubule structure by cryo-EM: snapshots of dynamic instability.Essays in biochemistry · 2018Review
- Structure and function of outer dynein arm intermediate and light chain complex.Molecular biology of the cell · 2016Article
- Genetics and biology of primary ciliary dyskinesia.Paediatric respiratory reviews · 2016Review
- Article
- Big steps toward understanding dynein.The Journal of cell biology · 2013Review
- Ultrastructural analysis of flagellar development in plurilocular sporangia of Ectocarpus siliculosus (Phaeophyceae).Protoplasma · 2013Article
- Integrated control of axonemal dynein AAA(+) motors.Journal of structural biology · 2012Review
- Functional architecture of the outer arm dynein conformational switch.The Journal of biological chemistry · 2012Article
- A physical model reveals the mechanochemistry responsible for dynein's processive motion.Biophysical journal · 2011Article
- Regulation of ciliary motility: conserved protein kinases and phosphatases are targeted and anchored in the ciliary axoneme.Archives of biochemistry and biophysics · 2011Review
- Distinct roles of 1alpha and 1beta heavy chains of the inner arm dynein I1 of Chlamydomonas flagella.Molecular biology of the cell · 2011Article
- Axonemal dyneins winch the cilium.Nature structural & molecular biology · 2010Article
- Sensing the mechanical state of the axoneme and integration of Ca2+ signaling by outer arm dynein.Cytoskeleton (Hoboken, N.J.) · 2010Review
- Asymmetry of inner dynein arms and inter-doublet links in Chlamydomonas flagella.The Journal of cell biology · 2009Article
- An outer arm dynein light chain acts in a conformational switch for flagellar motility.The Journal of cell biology · 2009Article
- Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
Abstract
The outer dynein arms (ODAs) of the flagellar axoneme generate forces needed for flagellar beating. Elucidation of the mechanisms underlying the chemomechanical energy conversion by the dynein arms and their orchestrated movement in cilia/flagella is of great importance, but the nucleotide-dependent three-dimensional (3D) movement of dynein has not yet been observed. In this study, we establish a new method for reconstructing the 3D structure of the in vitro reconstituted ODA-microtubule complex and visualize nucleotide-dependent conformational changes using cryoelectron microscopy and image analysis. As the complex went from the rigor state to the relaxed state, the head domain of the beta heavy chain shifted by 3.7 nm toward the B tubule and inclined 44 degrees inwards. These observations suggest that there is a mechanism that converts head movement into the axonemal sliding motion.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.