ArticleAntimicrobial agents and chemotherapy2007
In vitro susceptibility of Sporothrix schenckii to six antifungal agents determined using three different methods.
Article in Antimicrobial agents and chemotherapy, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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12 citing papers in PubMed, 55 citations in OpenAlex.
- In Vitro Antifungal Drug Susceptibility of Feline Sporothrix schenckii Complex Isolates, Thailand, 2023-2025.Emerging infectious diseases · 2026Article
- Milteforan, a promising veterinary commercial product against feline sporotrichosis.Microbiology spectrum · 2024Article
- Milteforan, a promising veterinary commercial product against feline sporotrichosis.bioRxiv : the preprint server for biology · 2024Article
- Phenotypic and molecular characterisation of Sporothrix globosa of diverse origin from India.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2021Article
- Antifungal Susceptibility Testing: Current Approaches.Clinical microbiology reviews · 2020Review
- Multicenter, International Study of MIC/MEC Distributions for Definition of Epidemiological Cutoff Values for Sporothrix Species Identified by Molecular Methods.Antimicrobial agents and chemotherapy · 2017Article
- Minimal inhibitory concentration distributions and epidemiological cutoff values of five antifungal agents against Sporothrix brasiliensis.Memorias do Instituto Oswaldo Cruz · 2017Article
- Disseminated sporotrichosis in an immunocompetent patient.Case reports in plastic surgery & hand surgery · 2016Article
- Sporothrix schenckii and Sporotrichosis.Clinical microbiology reviews · 2011Review
- Evaluation of the origin of a sample of Sporothrix schenckii that caused contamination of a researcher in Southern Brazil.Mycopathologia · 2011Article
- Nodular lymphangitis: a distinctive clinical entity with finite etiologies.Current infectious disease reports · 2008Article
- Sporothrix schenckii COMPLEX:SUSCEPTIBILITIES TO COMBINED ANTIFUNGAL AGENTS AND CHARACTERIZATION OF ENZYMATIC PROFILES.Revista do Instituto de Medicina Tropical de Sao PauloArticle
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The in vitro susceptibility of Sporothrix schenckii to antifungal drugs has been determined with three different methods. Nineteen Peruvian clinical isolates of S. schenckii were tested against amphotericin B (AB), flucytosine (FC), fluconazole (FZ), itraconazole (IZ), voriconazole (VZ), and ketoconazole (KZ). Modified NCCLS M38-A, Sensititre YeastOne (SYO), and ATB Fungus 2 (ATBF2) methods were used to determine the MICs. ATCC isolates of Candida parapsilosis, Candida krusei, and Aspergillus flavus were used for quality control. Sporothrix inocula were prepared with the mycelial form growing on potato dextrose agar at 28 +/- 2 degrees C. MICs of AB, FC, FZ, and IZ were determined with all three methods, VZ with M38-A and SYO, and KZ with only SYO. The three methods showed high MICs of FZ and FC (MIC(90) of 0.5 microg/ml), being homogeneously lower than those of IZ and KZ. The M38-A method showed a variable MIC range of VZ (4.0 to 16 microg/ml); the geometric mean (GM) was 9.3 mug/ml. The MIC range of AB was wide (0.06 to 16 microg/ml), but the GM was 1.2 microg/ml, suggesting that the MIC is strain dependent. Agreement (two log(2) dilutions) between commercial techniques and the modified M38-A method was very high with FZ, IZ, and FC. In AB and VZ, the agreement was lower, being related to the antifungal concentrations of each method. The highest activity against S. schenckii was found with IZ and KZ. Lack of activity was observed with FZ, VZ, and FC. When AB is indicated for sporotrichosis, the susceptibility of the strain must be analyzed. Commercial quantitative antifungal methods have a limited usefulness in S. schenckii.
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