ArticleInfection and immunity2007
A functional NADPH oxidase prevents caspase involvement in the clearance of phagocytic neutrophils.
Article in Infection and immunity, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
14 citing papers in PubMed, 37 citations in OpenAlex.
- The Challenges of Detecting Neutrophil CFTR.Journal of innate immunity · 2026Review
- Modulatory role of vitamins A, B3, C, D, and E on skin health, immunity, microbiome, and diseases.Pharmacological reports : PR · 2023Review
- Neutrophils: Many Ways to Die.Frontiers in immunology · 2021Review
- Inflammasomes: Pandora's box for sepsis.Journal of inflammation research · 2018Review
- Vitamin C and Immune Function.Nutrients · 2017Review
- Article
- NADPH oxidase inhibits the pathogenesis of systemic lupus erythematosus.Science translational medicine · 2012Article
- Dying for a cause: NETosis, mechanisms behind an antimicrobial cell death modality.Cell death and differentiation · 2011Review
- Neutrophil extracellular trap cell death requires both autophagy and superoxide generation.Cell research · 2011Article
- Article
- Article
- Oxidative stress-induced changes in pyridine nucleotides and chemoattractant 5-lipoxygenase products in aging neutrophils.Free radical biology & medicine · 2009Article
- Bcl-2 family proteins as regulators of oxidative stress.Seminars in cancer biology · 2009Review
- Oxidative stress in sepsis. Possible production of free radicals through an erythrocyte-mediated positive feedback mechanism.The Brazilian journal of infectious diseases : an official publication of the Brazilian Society of Infectious DiseasesArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Neutrophils play a prominent role in host defense. Phagocytosis of bacteria leads to the formation of an active NADPH oxidase complex that generates reactive oxygen species for bactericidal purposes. A critical step in the resolution of inflammation is the uptake of neutrophils by macrophages; however, there are conflicting reports on the mechanisms leading to the apoptosis of phagocytic neutrophils. The aim of this study was to clarify the role of effector caspases in these processes. Caspase activity was measured by DEVDase activity assays or immunofluorescence detection of active caspase-3. With normal human and wild-type murine neutrophils there was no caspase activation following phagocytosis of Staphylococcus aureus. However, caspase activity was observed in phagocytic neutrophils with a defective NADPH oxidase, including neutrophils isolated from X-linked gp91(phox) knockout chronic granulomatous disease mice. These results indicate that a functional NADPH oxidase and the generation of oxidants in the neutrophil phagosome prevent the activation of the cytoplasmic caspase cascade.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.