ArticleGenes & development2007
Polycomb genes interact with the tumor suppressor genes hippo and warts in the maintenance of Drosophila sensory neuron dendrites.
Article in Genes & development, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
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Who cites it
37 citing papers in PubMed, 86 citations in OpenAlex.
- Region-specific mechanosensation modulateseLife · 2026Article
- Polycomb group genes are required for neuronal pruning in Drosophila.BMC biology · 2023Article
- Counteracting epigenetic mechanisms regulate the structural development of neuronal circuitry in human neurons.Molecular psychiatry · 2022Article
- Persistent epigenetic reprogramming of sweet taste by diet.Science advances · 2020Article
- Drosophila miR-87 promotes dendrite regeneration by targeting the transcriptional repressor Tramtrack69.PLoS genetics · 2020Article
- A Localized Scaffold for cGMP Increase Is Required for Apical Dendrite Development.Cell reports · 2020Article
- Scrap and Build for Functional Neural Circuits: Spatiotemporal Regulation of Dendrite Degeneration and Regeneration in Neural Development and Disease.Frontiers in cellular neuroscience · 2020Review
- Involvement of YAP-1, the Homolog of Yes-Associated Protein, in the Wnt-Mediated Neuronal Polarization inG3 (Bethesda, Md.) · 2018Article
- Phospholipid Homeostasis Regulates Dendrite Morphogenesis in Drosophila Sensory Neurons.Cell reports · 2017Article
- Dendritic space-filling requires a neuronal type-specific extracellular permissive signal inProceedings of the National Academy of Sciences of the United States of America · 2017Article
- Drosophila caspase activity is required independently of apoptosis to produce active TNF/Eiger during nociceptive sensitization.Cell death & disease · 2017Article
- Life and death rest on a bivalent chromatin state.Nature neuroscience · 2016Article
- MicroRNA-214 Promotes Dendritic Development by Targeting the Schizophrenia-associated Gene Quaking (Qki).The Journal of biological chemistry · 2016Article
- Review
- Article
- LATS2 Positively Regulates Polycomb Repressive Complex 2.PloS one · 2016Article
- Regulation of dendrite growth and maintenance by exocytosis.Journal of cell science · 2015Article
- Discovery of Rare Mutations in Autism: Elucidating Neurodevelopmental Mechanisms.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2015Review
- The Ret receptor regulates sensory neuron dendrite growth and integrin mediated adhesion.eLife · 2015Article
- Double-bromo and extraterminal (BET) domain proteins regulate dendrite morphology and mechanosensory function.Genes & development · 2014Article
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Dendritic fields are important determinants of neuronal function. However, how neurons establish and then maintain their dendritic fields is not well understood. Here we show that Polycomb group (PcG) genes are required for maintenance of complete and nonoverlapping dendritic coverage of the larval body wall by Drosophila class IV dendrite arborization (da) neurons. In esc, Su(z)12, or Pc mutants, dendritic fields are established normally, but class IV neurons display a gradual loss of dendritic coverage, while axons remain normal in appearance, demonstrating that PcG genes are specifically required for dendrite maintenance. Both multiprotein Polycomb repressor complexes (PRCs) involved in transcriptional silencing are implicated in regulation of dendrite arborization in class IV da neurons, likely through regulation of homeobox (Hox) transcription factors. We further show genetic interactions and association between PcG proteins and the tumor suppressor kinase Warts (Wts), providing evidence for their cooperation in multiple developmental processes including dendrite maintenance.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.