ArticleBMC genomics2007
An insight into the sialome of the oriental rat flea, Xenopsylla cheopis (Rots).
Article in BMC genomics, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.
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Who cites it
40 citing papers in PubMed, 84 citations in OpenAlex.
- An insight into the draft genome of the Oriental rat flea, Xenopsylla cheopis, together with its Wolbachia endosymbiont.BMC genomics · 2025Article
- Mosquito salivary apyrase regulates blood meal hemostasis and facilitates malaria parasite transmission.Nature communications · 2024Article
- Transcriptome analysis of Kunming mice responses to the bite of Xenopsylla cheopis.Parasites & vectors · 2024Article
- Metabolism and immune responses of striped hamsters to ectoparasite challenges: insights from transcriptomic analysis.Frontiers in immunology · 2024Article
- Salivary glands of the cat flea,Current research in insect science · 2024Review
- Acid phosphatase-like proteins, a biogenic amine and leukotriene-binding salivary protein family from the flea Xenopsylla cheopis.Communications biology · 2023Article
- Advances in genome sequencing reveal changes in gene content that contribute to arthropod macroevolution.Development genes and evolution · 2023Review
- Article
- The biotechnological potential of proteases from hematophagous arthropod vectors.Frontiers in cellular and infection microbiology · 2023Article
- Article
- Integrated analysis of the sialotranscriptome and sialoproteome of the rat flea Xenopsylla cheopis.Journal of proteomics · 2022Article
- Using Proteomic Approaches to Unravel the Response ofFrontiers in cellular and infection microbiology · 2022Article
- Article
- Dynamic gene expression in salivary glands of the cat flea during Rickettsia felis infection.Pathogens and disease · 2021Article
- TickSialoFam (TSFam): A Database That Helps to Classify Tick Salivary Proteins, a Review on Tick Salivary Protein Function and Evolution, With Considerations on the Tick Sialome Switching Phenomenon.Frontiers in cellular and infection microbiology · 2020Review
- De novo RNA-seq and functional annotation of Ornithonyssus bacoti.Experimental & applied acarology · 2018Article
- Exploring the molecular complexity of Triatoma dimidiata sialome.Journal of proteomics · 2018Article
- A reverse vaccinology approach to the identification and characterization of Ctenocephalides felis candidate protective antigens for the control of cat flea infestations.Parasites & vectors · 2018Article
- Insights into the sand fly saliva: Blood-feeding and immune interactions between sand flies, hosts, and Leishmania.PLoS neglected tropical diseases · 2017Review
- Anopheline salivary protein genes and gene families: an evolutionary overview after the whole genome sequence of sixteen Anopheles species.BMC genomics · 2017Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundThe salivary glands of hematophagous animals contain a complex cocktail that interferes with the host hemostasis and inflammation pathways, thus increasing feeding success. Fleas represent a relatively recent group of insects that evolved hematophagy independently of other insect orders.
resultsAnalysis of the salivary transcriptome of the flea Xenopsylla cheopis, the vector of human plague, indicates that gene duplication events have led to a large expansion of a family of acidic phosphatases that are probably inactive, and to the expansion of the FS family of peptides that are unique to fleas. Several other unique polypeptides were also uncovered. Additionally, an apyrase-coding transcript of the CD39 family appears as the candidate for the salivary nucleotide hydrolysing activity in X.cheopis, the first time this family of proteins is found in any arthropod salivary transcriptome.
conclusionAnalysis of the salivary transcriptome of the flea X. cheopis revealed the unique pathways taken in the evolution of the salivary cocktail of fleas. Gene duplication events appear as an important driving force in the creation of salivary cocktails of blood feeding arthropods, as was observed with ticks and mosquitoes. Only five other flea salivary sequences exist at this time at NCBI, all from the cat flea C. felis. This work accordingly represents the only relatively extensive sialome description of any flea species. Sialotranscriptomes of additional flea genera will reveal the extent that these novel polypeptide families are common throughout the Siphonaptera.
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Registered trials
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