ArticleMolecular cancer2007
Cancer cell: using inflammation to invade the host.
Article in Molecular cancer, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed, 46 citations in OpenAlex.
- Gene-Expression Programs in Salivary Gland Adenoid Cystic Carcinoma Analyzed Using Single-Cell and Spatial Transcriptomics.bioRxiv : the preprint server for biology · 2025Article
- The role of programmed death receptor (PD-)1/PD-ligand (L)1 in periodontitis and cancer.Periodontology 2000 · 2024Review
- Hyaluronic acid-based nano drug delivery systems for breast cancer treatment: Recent advances.Frontiers in bioengineering and biotechnology · 2022Review
- Stemness, Inflammation and Epithelial-Mesenchymal Transition in Colorectal Carcinoma: The Intricate Network.International journal of molecular sciences · 2021Review
- Cancer vs. SARS-CoV-2 induced inflammation, overlapping functions, and pharmacological targeting.Inflammopharmacology · 2021Review
- Cancer Stem-Like Cells in a Case of an Inflammatory Myofibroblastic Tumor of the Lung.Frontiers in oncology · 2020Article
- Carcinogenesis: the cancer cell-mast cell connection.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2019Review
- Association between inflammation and cancer stem cell phenotype in breast cancer.Oncology letters · 2018Article
- Expression of chemerin correlates with a poor prognosis in female breast cancer patients.Breast cancer (Dove Medical Press) · 2018Article
- Naturally occurring compounds acting as potent anti-metastatic agents and their suppressing effects on Hedgehog and WNT/β-catenin signalling pathways.Cell proliferation · 2017Review
- Microbial pigments as natural color sources: current trends and future perspectives.Journal of food science and technology · 2015Review
- Article
- Magnetic-based multi-layer microparticles for endothelial progenitor cell isolation, enrichment, and detachment.Biomaterials · 2014Article
- Inflammation promotes oral squamous carcinoma immune evasion via induced programmed death ligand-1 surface expression.Oncology letters · 2013Article
- Could cancer initiate from bone marrow progenitors?Iranian journal of cancer prevention · 2013Review
- Myeloid cells positive for CD10 at invasion front can predict poor outcome in stage II colorectal cancer.International journal of clinical oncology · 2012Article
- The Amazing Power of Cancer Cells to Recapitulate Extraembryonic Functions: The Cuckoo's Tricks.Journal of oncology · 2012Article
- The use of chemokine-releasing tissue engineering scaffolds in a model of inflammatory response-mediated melanoma cancer metastasis.Biomaterials · 2012Article
- Pathological axes of wound repair: gastrulation revisited.Theoretical biology & medical modelling · 2010Article
- Epithelial-mesenchymal transition: a cancer researcher's conceptual friend and foe.The American journal of pathology · 2009Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundInflammation is increasingly recognized as an important component of tumorigenesis, although the mechanisms involved are not fully characterized. The invasive capacity of cancers is reflected in the classic metastatic cascade: tumor (T), node (N) and metastasis (M). However, this staging system for cancer would also have a tumoral biological significance. PRESENTATION OF THE HYPOTHESIS: To integrate the mechanisms that control the inflammatory response in the actual staging system of cancer. It is considered that in both processes of inflammation and cancer, three successive phenotypes are presented that represent the expression of trophic functional systems of increasing metabolic complexity for using oxygen. TESTING THE HYPOTHESIS: While a malignant tumor develops it express phenotypes that also share the inflammatory response such as: an ischemic phenotype (anoxic-hypoxic), a leukocytic phenotype with anaerobic glycolysis and migration, and an angiogenic phenotype with hyperactivity of glycolytic enzymes, tumor proliferation and metastasis, and cachexia of the host. The increasing metabolic complexity of the tumor cell to use oxygen allows for it to be released, migrate and proliferate, thus creating structures of growing complexity. IMPLICATION OF THE HYPOTHESIS: One aim of cancer gene therapy could be the induction of oxidative phosphorylation, the last metabolic step required by inflammation in order to differentiate the tissue that it produces.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.