ArticleBMC molecular biology2007
Identification of a set of KSRP target transcripts upregulated by PI3K-AKT signaling.
Article in BMC molecular biology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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Who cites it
33 citing papers in PubMed, 60 citations in OpenAlex.
- Balancing LncRNA H19 and miR-675 Bioconversion as a Key Regulator of Embryonic Myogenesis Under Maternal Obesity.Journal of cachexia, sarcopenia and muscle · 2025Article
- Expanding the Functions of KHSRP Protein: Insights into DNA G-Quadruplex Binding.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- CTGF facilitates cell-cell communication in chondrocytes via PI3K/Akt signalling pathway.Cell proliferation · 2021Article
- Aging and Protein Kinases.Advances in experimental medicine and biology · 2021Article
- Review
- Aberrant MicroRNAomics in Pulmonary Complications: Implications in Lung Health and Diseases.Molecular therapy. Nucleic acids · 2019Review
- K-homology splicing regulatory protein (KSRP) promotes post-transcriptional destabilization of Spry4 transcripts in non-small cell lung cancer.The Journal of biological chemistry · 2017Article
- Hallmarks of cancer and AU-rich elements.Wiley interdisciplinary reviews. RNA · 2017Review
- Implication of Long noncoding RNAs in the endothelial cell response to hypoxia revealed by RNA-sequencing.Scientific reports · 2016Article
- 5-HT2A and 5-HT2C receptors as hypothalamic targets of developmental programming in male rats.Disease models & mechanisms · 2016Article
- KHSRP participates in manganese-induced neurotoxicity in rat striatum and PC12 cells.Journal of molecular neuroscience : MN · 2015Article
- HnRNP A1 tethers KSRP to an exon splicing silencer that inhibits an erythroid-specific splicing event in PU.1-induced erythroleukemia.American journal of cancer research · 2015Article
- H19 long noncoding RNA controls the mRNA decay promoting function of KSRP.Proceedings of the National Academy of Sciences of the United States of America · 2014Article
- A novel posttranscriptional mechanism for dietary cholesterol-mediated suppression of liver LDL receptor expression.Journal of lipid research · 2014Article
- Role of KSRP in control of type I interferon and cytokine expression.Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research · 2014Review
- The RNA-binding protein hnRNPA2 regulates β-catenin protein expression and is overexpressed in prostate cancer.RNA biology · 2014Article
- Peptides modeled on the RGG domain of AUF1/hnRNP-D regulate 3' UTR-dependent gene expression.International immunopharmacology · 2013Article
- SRSF1 and SRSF9 RNA binding proteins promote Wnt signalling-mediated tumorigenesis by enhancing β-catenin biosynthesis.EMBO molecular medicine · 2013Article
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- Review
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 3 countries.
Funding
Abstract
backgroundKSRP is a AU-rich element (ARE) binding protein that causes decay of select sets of transcripts in different cell types. We have recently described that phosphatidylinositol 3-kinase/AKT (PI3K-AKT) activation induces stabilization and accumulation of the labile beta-catenin mRNA through an impairment of KSRP function.
resultsAim of this study was to identify additional KSRP targets whose stability and steady-state levels are enhanced by PI3K-AKT activation. First, through microarray analyses of the AU-rich transcriptome in pituitary alphaT3-1 cells, we identified 34 ARE-containing transcripts upregulated in cells expressing a constitutively active form of AKT1. In parallel, by an affinity chromatography-based technique followed by microarray analyses, 12 mRNAs target of KSRP, additional to beta-catenin, were identified. Among them, seven mRNAs were upregulated in cells expressing activated AKT1. Both steady-state levels and stability of these new KSRP targets were consistently increased by either KSRP knock-down or PI3K-AKT activation.
conclusionOur study identified a set of transcripts that are targets of KSRP and whose expression is increased by PI3K-AKT activation. These mRNAs encode RNA binding proteins, signaling molecules and a replication-independent histone. The increased expression of these gene products upon PI3K-AKT activation could play a role in the cellular events initiated by this signaling pathway.
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Registered trials
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