ReviewImmunology2007
BAC to immunology--bacterial artificial chromosome-mediated transgenesis for targeting of immune cells.
Review in Immunology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
14 citing papers in PubMed, 40 citations in OpenAlex.
- A scalable two-step genome editing strategy for generating full-length gene-humanized mice at diverse genomic loci.Nature communications · 2026Article
- Visualization of T Cell Migration in the Spleen Reveals a Network of Perivascular Pathways that Guide Entry into T Zones.Immunity · 2020Article
- Origin and differentiation trajectories of fibroblastic reticular cells in the splenic white pulp.Nature communications · 2019Article
- Endogenous Expression of the Human CD83 Attenuates EAE Symptoms in Humanized Transgenic Mice and Increases the Activity of Regulatory T Cells.Frontiers in immunology · 2019Article
- Article
- RNA recognition by human TLR8 can lead to autoimmune inflammation.The Journal of experimental medicine · 2013Article
- Article
- Application of a bacterial artificial chromosome modification system for a human artificial chromosome vector.Yonago acta medica · 2011Article
- In vivo analysis of mouse gastrin gene regulation in enhanced GFP-BAC transgenic mice.American journal of physiology. Gastrointestinal and liver physiology · 2011Article
- A novel bacterial artificial chromosome-transgenic podoplanin-cre mouse targets lymphoid organ stromal cells in vivo.Frontiers in immunology · 2011Article
- Cell type-specific regulation of IL-10 expression in inflammation and disease.Immunologic research · 2010Review
- Red-mediated transposition and final release of the mini-F vector of a cloned infectious herpesvirus genome.PloS one · 2009Article
- A human IL10 BAC transgene reveals tissue-specific control of IL-10 expression and alters disease outcome.Proceedings of the National Academy of Sciences of the United States of America · 2009Article
- Dynamic DNA methylation patterns across the mouse and human IL10 genes during CD4+ T cell activation; influence of IL-27.Molecular immunologyArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Thirty years after the first transgenic mouse was produced, a plethora of genetic tools has been developed to study immune cells in vivo. A powerful development is the bacterial artificial chromosome (BAC) transgenic approach, combining advantages of both conventional transgenic and knock-in gene-targeting strategies. In immunology the potential of BAC transgenic technology has yet to be fully harvested and, combined with a variety of elegant genetic tools, it will allow the analysis of complex immunological processes in vivo. In this short review, we discuss the applications of BACs in immunology, such as identification of regulatory regions, expression and cell-fate mapping, cell ablation, conditional mutations and the generation of humanized mice.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.