ArticleHuman brain mapping2007
Mouse behavioral mutants have neuroimaging abnormalities.
Article in Human brain mapping, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 44 citations in OpenAlex.
- Probing the Influence of Paternal Diet on Offspring Neuroanatomy With Mouse MRI.Brain and behavior · 2026Article
- Neurodevelopmental Impacts of Ketamine and Alfaxalone Anesthesia Evaluated with Mouse MRI.Journal of the American Association for Laboratory Animal Science : JAALAS · 2025Article
- Host genetics maps to behaviour and brain structure in developmental mice.Behavioral and brain functions : BBF · 2025Article
- Magnetic Resonance Imaging to Detect Structural Brain Changes in Huntington's Disease: A Review of Data from Mouse Models.Journal of Huntington's disease · 2024Review
- Metformin effects on brain development following cranial irradiation in a mouse model.Neuro-oncology · 2021Article
- Article
- Analysis of neuroanatomical differences in mice with genetically modified serotonin transporters assessed by structural magnetic resonance imaging.Molecular autism · 2018Article
- Larger Numbers of Glial and Neuronal Cells in the Periaqueductal Gray Matter of μ-Opioid Receptor Knockout Mice.Frontiers in psychiatry · 2018Article
- Article
- A simple rapid process for semi-automated brain extraction from magnetic resonance images of the whole mouse head.Journal of neuroscience methods · 2016Article
- Behavioral and Neuroanatomical Phenotypes in Mouse Models of Autism.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2015Review
- Clustering autism: using neuroanatomical differences in 26 mouse models to gain insight into the heterogeneity.Molecular psychiatry · 2015Article
- Gestational ketogenic diet programs brain structure and susceptibility to depression & anxiety in the adult mouse offspring.Brain and behavior · 2015Article
- Specific regions display altered grey matter volume in μ-opioid receptor knockout mice: MRI voxel-based morphometry.British journal of pharmacology · 2015Article
- Behavioral abnormalities and circuit defects in the basal ganglia of a mouse model of 16p11.2 deletion syndrome.Cell reports · 2014Article
- Genetic effects on cerebellar structure across mouse models of autism using a magnetic resonance imaging atlas.Autism research : official journal of the International Society for Autism Research · 2014Article
- Neuroanatomical phenotypes in a mouse model of the 22q11.2 microdeletion.Molecular psychiatry · 2014Article
- MRI analysis of cerebellar and vestibular developmental phenotypes in Gbx2 conditional knockout mice.Magnetic resonance in medicine · 2013Article
- Automated segmentation of mouse brain images using multi-atlas multi-ROI deformation and label fusion.Neuroinformatics · 2013Article
- Neuroanatomical phenotyping of the mouse brain with three-dimensional autofluorescence imaging.Physiological genomics · 2012Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Impaired cognitive, memory, or motor performance is a distinguishing characteristic of neurological diseases. Although these symptoms are frequently the most evident in human patients, additional markers of disease are critical for proper diagnosis and staging. Noninvasive neuroimaging methods have become essential in this capacity and provide means of evaluating disease and tracking progression. These imaging methods are also becoming available to scientists in the research laboratory for assessment of animal models of neurological disease. Imaging in mouse models of neurological disease is of particular interest, owing to the availability of inbred strains and genetic manipulation tools that permit detailed investigation of the roles of various genes and gene products in disease pathogenesis. However, the relative prevalence of neuroimaging abnormalities in mice exhibiting neurological symptoms has not been reported. This prevalence has both theoretical and practical value because it is influenced by both the sensitivity of macroscopic anatomical measures to underlying genetic and disease processes and by the efficiency of neuroimaging in detecting and characterizing these effects. In this paper, we describe a meta-analysis of studies involving behavioral mouse mutants at our laboratory. In summary, we have evaluated 15 different mutant genotypes, of which 13 showed abnormal neuroimaging findings. This indicates a surprisingly high prevalence of neuroimaging abnormalities (87%) and suggests that disease processes affecting behavior generally alter neuroanatomy as well. As a consequence, neuroimaging provides a highly sensitive marker of neurological disease in mice exhibiting abnormal behavior.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.