ArticleEuropean journal of nuclear medicine and molecular imaging2007
Comparison of 99mTc-annexin A5 with 18F-FDG for the detection of atherosclerosis in ApoE-/- mice.
Article in European journal of nuclear medicine and molecular imaging, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed.
- Annexins and cardiovascular diseases: Beyond membrane trafficking and repair.Frontiers in cell and developmental biology · 2022Review
- Development of an inflammation imaging tracer,Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2019Article
- Tissue volume and activity mapping using total intensity projection of PET/CT images.American journal of nuclear medicine and molecular imaging · 2019Article
- Immunoglobulin G (IgG)-Based Imaging Probe Accumulates in M1 Macrophage-Infiltrated Atherosclerotic Plaques Independent of IgG Target Molecule Expression.Molecular imaging and biology · 2017Article
- A review of molecular imaging of atherosclerosis and the potential application of dendrimer in imaging of plaque.International journal of nanomedicine · 2017Review
- Recent Advances in the Development of PET/SPECT Probes for Atherosclerosis Imaging.Nuclear medicine and molecular imaging · 2016Review
- Targeting macrophage necroptosis for therapeutic and diagnostic interventions in atherosclerosis.Science advances · 2016Article
- Article
- Development of a radioiodinated triazolopyrimidine probe for nuclear medical imaging of fatty acid binding protein 4.PloS one · 2014Article
- Multi-radionuclide digital autoradiography of the intra-aortic atherosclerotic plaques using a monoclonal antibody targeting oxidized low-density lipoprotein.American journal of nuclear medicine and molecular imaging · 2014Article
- Recent advances in metabolic imaging.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2013Review
- Glucose metabolic trapping in mouse arteries: nonradioactive assay of atherosclerotic plaque inflammation applicable to drug discovery.PloS one · 2012Article
- Localization of deoxyglucose and annexin A5 in experimental atheroma correlates with macrophage infiltration but not lipid deposition in the lesion.Molecular imaging and biology · 2011Article
- Performance characterization of the Inveon preclinical small-animal PET/SPECT/CT system for multimodality imaging.European journal of nuclear medicine and molecular imaging · 2011Article
- Imaging with radiolabelled anti-membrane type 1 matrix metalloproteinase (MT1-MMP) antibody: potentials for characterizing atherosclerotic plaques.European journal of nuclear medicine and molecular imaging · 2010Article
- (18)F-fluorodeoxyglucose PET imaging of coronary atherosclerosis and plaque inflammation.Current cardiology reports · 2010Article
- Vulnerable plaque imaging-current techniques.Journal of cardiovascular translational research · 2009Review
- Pre-clinical and clinical evaluation of nuclear tracers for the molecular imaging of vulnerable atherosclerosis: an overview.Current medicinal chemistry · 2009Review
- Emerging role of FDG-PET/CT in assessing atherosclerosis in large arteries.European journal of nuclear medicine and molecular imaging · 2009Review
- Molecular imaging of atherosclerosis.Current cardiology reports · 2008Review
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8 authors.
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Abstract
purpose(99m)Tc-annexin A5, a marker of ongoing apoptosis, and (18)F-FDG, a marker of the increased metabolism of inflammatory cells, are supposed to be useful in the detection of metabolically active atheroma. This study reports a comparison of the intralesional distribution of these tracers in relation to lesion development in ApoE-/- mice.
methodsMale ApoE-/- mice (n = 12-14/group) were maintained on a Western-type diet after the age of 5 weeks. At 25 weeks, (99m)Tc-annexin A5 or (18)F-FDG was injected and the aortas were harvested for autoradiography (ARG) and Oil Red O staining. Regional radioactivity accumulation was compared in relation to the Oil Red O staining score (ranging from 0 to 3, a semiquantitative parameter for evaluating lesion development).
resultsBoth (99m)Tc-annexin A5 and (18)F-FDG showed preferential uptake into atherosclerotic lesions, with higher uptake levels for (18)F-FDG (mean, 56.07 %IDxkg/m(2)) than for (99m)Tc-annexin A5 (mean, 10.38 %IDxkg/m(2)). The regional uptake levels of each tracer correlated with the Oil Red O staining score (r = 0.65, p < 0.05 for (99m)Tc-annexin A5; r = 0.56, p < 0.05 for (18)F-FDG). The uptake ratios of advanced lesions (score >0.5) to early lesions (score <0.5) were significantly higher for (99m)Tc-annexin A5 than for (18)F-FDG (f = 4.73, p = 0.03).
conclusionBoth (99m)Tc-annexin A5 and (18)F-FDG accumulate in atherosclerotic lesions and correlate with the severity of each lesion. The higher absolute uptake levels of (18)F-FDG may be advantageous for lesion detection, whereas the preferential uptake of (99m)Tc-annexin A5 in advanced lesions may be a useful indicator of late-stage lesions or vulnerable plaque transformation.
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