ArticlePlant molecular biology2007
A functional genomics approach to (iso)flavonoid glycosylation in the model legume Medicago truncatula.
Article in Plant molecular biology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 62 papers.
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Who cites it
62 citing papers in PubMed.
- Genome-wide identification and expression analysis of the UGT gene family in honeysuckle.BMC plant biology · 2026Article
- Identification and Characterization of a Putative Kaempferol Glucosyltransferase UGT78G3 inPlants (Basel, Switzerland) · 2026Article
- Diversity and ecological functions of anthocyanins.BMC plant biology · 2025Review
- Genome-wide characterization of Solanum tuberosum UGT gene family and functional analysis of StUGT178 in salt tolerance.BMC genomics · 2024Article
- Identification and Functional Verification of the Glycosyltransferase Gene Family Involved in Flavonoid Synthesis inPlants (Basel, Switzerland) · 2024Article
- Whole-genome and genome-wide association studies improve key agricultural traits of safflower for industrial and medicinal use.Horticulture research · 2023Article
- Phylogenetic relationship and sequence diversity of candidate genes involved in anthocyanin biosynthesis pathway inPhysiology and molecular biology of plants : an international journal of functional plant biology · 2023Article
- Evaluation of pathways to thePlant direct · 2022Article
- Leaf Coloration inPlants (Basel, Switzerland) · 2022Article
- Glycosyltransferases: Mining, engineering and applications in biosynthesis of glycosylated plant natural products.Synthetic and systems biotechnology · 2022Article
- Integrated metabolomics and transcriptome analysis on flavonoid biosynthesis in flowers of safflower (PeerJ · 2022Article
- Family 1 glycosyltransferases (GT1, UGTs) are subject to dilution-induced inactivation and low chemo stability toward their own acceptor substrates.Frontiers in molecular biosciences · 2022Article
- Flavonoid Accumulation Varies inFrontiers in plant science · 2022Article
- Characterization of Two Key Flavonoid 3-Frontiers in plant science · 2022Article
- UGT84F9 is the major flavonoid UDP-glucuronosyltransferase in Medicago truncatula.Plant physiology · 2021Article
- The chromosome-level reference genome assembly forPlant communications · 2021Article
- Article
- Genome-Wide Association Study Reveals Complex Genetic Architecture of Cadmium and Mercury Accumulation and Tolerance Traits inFrontiers in plant science · 2021Article
- Flavonoids and Isoflavonoids Biosynthesis in the Model LegumePlants (Basel, Switzerland) · 2020Review
- Identification of Three (Iso)flavonoid Glucosyltransferases FromFrontiers in plant science · 2019Article
2 more citing papers are in PubMed but not listed here.
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Analysis of over 200,000 expressed sequence tags from a range of Medicago truncatula cDNA libraries resulted in the identification of over 150 different family 1 glycosyltransferase (UGT) genes. Of these, 63 were represented by full length clones in an EST library collection. Among these, 19 gave soluble proteins when expressed in E. coli, and these were screened for catalytic activity against a range of flavonoid and isoflavonoid substrates using a high-throughput HPLC assay method. Eight UGTs were identified with activity against isoflavones, flavones, flavonols or anthocyanidins, and several showed high catalytic specificity for more than one class of (iso)flavonoid substrate. All tested UGTs preferred UDP-glucose as sugar donor. Phylogenetic analysis indicated that the Medicago (iso)flavonoid glycosyltransferase gene sequences fell into a number of different clades, and several clustered with UGTs annotated as glycosylating non-flavonoid substrates. Quantitative RT-PCR and DNA microarray analysis revealed unique transcript expression patterns for each of the eight UGTs in Medicago organs and cell suspension cultures, and comparison of these patterns with known phytochemical profiles suggested in vivo functions for several of the enzymes.
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