ArticleCroatian medical journal2007
Circulating lymphocyte subsets, natural killer cell cytotoxicity, and components of hypothalamic-pituitary-adrenal axis in Croatian war veterans with posttraumatic stress disorder: cross-sectional study.
Article in Croatian medical journal, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
What it found
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Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it, 55 citations in OpenAlex.
- Relations among posttraumatic stress disorder, comorbid major depression, and HPA function: a systematic review and meta-analysis.Clinical psychology review · 2012Pooled it
- Psychological Scars and Physical Consequences: Linking PTSD to Cardiovascular Health.Journal of cardiovascular translational research · 2026Review
- Causal associations between immune cells and psychiatric disorders: a bidirectional mendelian randomization analysis.Naunyn-Schmiedeberg's archives of pharmacology · 2025Article
- Innate and adaptive immune system consequences of post-traumatic stress disorder.Autonomic neuroscience : basic & clinical · 2024Review
- Apoptosis Evaluation in Circulating CD34+-Enriched Hematopoietic Stem and Progenitor Cells in Patients with Abnormally Increased Production of Endogenous Glucocorticoids in Course of Cushing's Syndrome.International journal of molecular sciences · 2022Article
- Central and Peripheral Immune Dysregulation in Posttraumatic Stress Disorder: Convergent Multi-Omics Evidence.Biomedicines · 2022Review
- Innate Immunity: A Common Denominator between Neurodegenerative and Neuropsychiatric Diseases.International journal of molecular sciences · 2020Review
- Methylomic profiles reveal sex-specific differences in leukocyte composition associated with post-traumatic stress disorder.Brain, behavior, and immunity · 2019Article
- Autonomic and inflammatory consequences of posttraumatic stress disorder and the link to cardiovascular disease.American journal of physiology. Regulatory, integrative and comparative physiology · 2015Review
- Post-traumatic stress disorder: revisiting adrenergics, glucocorticoids, immune system effects and homeostasis.Clinical & translational immunology · 2014Review
- Patients with posttraumatic stress disorder exhibit an altered phenotype of regulatory T cells.Allergy, asthma, and clinical immunology : official journal of the Canadian Society of Allergy and Clinical Immunology · 2014Article
- Article
- Spiritual well-being, cortisol, and suicidality in Croatian war veterans suffering from PTSD.Journal of religion and health · 2011Article
- Are the elderly more vulnerable to psychological impact of natural disaster? A population-based survey of adult survivors of the 2008 Sichuan earthquake.BMC public health · 2010Article
- Low cortisol, high DHEA, and high levels of stimulated TNF-alpha, and IL-6 in women with PTSD.Journal of traumatic stress · 2008Article
- Changes in plasma lipid concentrations and risk of coronary artery disease in army veterans suffering from chronic posttraumatic stress disorder.Croatian medical journal · 2008Article
- Evaluation of steroid hormone receptor protein expression in intact cells using flow cytometry.Nuclear receptor signaling · 2007Article
- Military combat and burden of subclinical atherosclerosis in middle aged men: the ARIC study.Preventive medicineArticle
- Topical Review: The Emerging Field of Epigenetics: Informing Models of Pediatric Trauma and Physical Health.Journal of pediatric psychologyReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimTo determine peripheral blood lymphocyte subsets--T cells, helper T cells, cytotoxic T cells, B cells, and natural killer cells, natural killer cell cytotoxicity, serum cortisol concentration, and lymphocyte glucocorticoid receptor expression in Croatian combat veterans diagnosed with chronic posttraumatic stress disorder (PTSD); and to examine the relationship between the assessed parameters and the time passed since the traumatic experience.
methodsWell-characterized group of 38 PTSD patients was compared to a group of 24 healthy civilians. Simultaneous determination of lymphocyte subsets and the expression of intracellular glucocorticoid receptor was performed using three-color flow cytometry. Natural killer cell cytotoxicity was measured by (51)Cr-release assay and the serum cortisol concentration was determined by radioimmunoassay.
resultsWe found higher lymphocyte counts in PTSD patients than in healthy controls (2294.7+/-678.0/microL vs 1817.2+/-637.0/microL, P=0.007) and a positive correlation between lymphocyte glucocorticoid receptor expression and the number of years that passed from the traumatic experience (r(s)=0.43, P=0.008). Lymphocyte glucocorticoid receptor expression positively correlated with serum cortisol concentration both in PTSD patients (r=0.46, P=0.006) and healthy controls (r=0.46, P=0.035).
conclusionThis study confirmed that the immune system was affected in the course of chronic PTSD. Our findings also indicated that the hypothalamic-pituitary-adrenal axis profile in PTSD was associated with the duration of the disorder. Due to the lack of power, greater sample sizes are needed to confirm the results of this study.
Indexed as
Identifiers
17436384PMC2080521W2163143776What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.