Evidence map›Paper›PMID 17436249›Full record

ArticleAmerican journal of human genetics2007

Measuring European population stratification with microarray genotype data.

Marc Bauchet, Brian McEvoy, Laurel N Pearson, Ellen E Quillen, Tamara Sarkisian, Kristine Hovhannesyan, Ranjan Deka, Daniel G Bradley, Mark D Shriver

Abstract read
In one paragraph

Article in American journal of human genetics, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 86 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
86citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

86 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
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  7. Genetic history of the population of Crete.Annals of human genetics · 2019
    Article
  8. Mitochondrial DNA variability of the Polish population.European journal of human genetics : EJHG · 2019
    Article
  9. Replication study of GWAS risk loci in Greek multiple sclerosis patients.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2019
    Article
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26 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Marc BauchetDepartment of Anthropology, Pennsylvania State University, University Park, PA 16801, USA. marcb@psu.edu
Brian McEvoy
Laurel N Pearson
Ellen E Quillen
Tamara Sarkisian
Kristine Hovhannesyan
Ranjan Deka
Daniel G Bradley
Mark D Shriver

Funding

CONSTRUCTION AND APPLICATION OF A US ADMIXTURE MAPR01HG002154 · NHGRI · PENNSYLVANIA STATE UNIVERSITY-UNIV PARK · PI SHRIVER, MARK D · 1999 to 2006
$1.7M
NHGRI NIH HHS HG002154NHGRI NIH HHS R01 HG002154
6 · The paper itself

Abstract

A proper understanding of population genetic stratification--differences in individual ancestry within a population--is crucial in attempts to find genes for complex traits through association mapping. We report on genomewide typing of approximately 10,000 single-nucleotide polymorphisms in 297 individuals, to explore population structure in Europeans of known and unknown ancestry. The results reveal the presence of several significant axes of stratification, most prominently in a northern-southeastern trend, but also along an east-west axis. We also demonstrate the selection and application of EuroAIMs (European ancestry informative markers) for ancestry estimation and correction. The Coriell Caucasian and CEPH (Centre d'Etude du Polymorphisme Humain) Utah sample panels, often used as proxies for European populations, are found to reflect different subsets of the continent's ancestry.

Indexed as

Genetics, PopulationData Interpretation, StatisticalEthnicityEuropeGenotypeHumansOligonucleotide Array Sequence AnalysisPolymorphism, Single NucleotideRacial Groups

Identifiers

PMID17436249
PMCPMC1852743

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.