ArticleNature methods2007
A model system for analyzing somatic mutations in Drosophila melanogaster.
Article in Nature methods, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 26 citations in OpenAlex.
- Revisiting the approaches to DNA damage detection in genetic toxicology: insights and regulatory implications.BioData mining · 2025Article
- The architecture of intra-organism mutation rate variation in plants.PLoS biology · 2019Article
- Genome instability: a conserved mechanism of ageing?Essays in biochemistry · 2017Review
- The various aspects of genetic and epigenetic toxicology: testing methods and clinical applications.Journal of translational medicine · 2017Review
- Frequent Somatic Mutation in Adult Intestinal Stem Cells Drives Neoplasia and Genetic Mosaicism during Aging.Cell stem cell · 2015Article
- High-throughput sequencing in mutation detection: A new generation of genotoxicity tests?Mutation research · 2015Review
- A new conceptual framework for investigating complex genetic disease.Frontiers in genetics · 2015Article
- Deficiency of the DNA repair protein nibrin increases the basal but not the radiation induced mutation frequency in vivo.Mutation research · 2014Article
- KDM5 interacts with Foxo to modulate cellular levels of oxidative stress.PLoS genetics · 2014Article
- Aging genomes: a necessary evil in the logic of life.BioEssays : news and reviews in molecular, cellular and developmental biology · 2014Review
- Myc-dependent genome instability and lifespan in Drosophila.PloS one · 2013Article
- Measuring genome instability in aging - a mini-review.Gerontology · 2012Review
- Loss of the bloom syndrome helicase increases DNA ligase 4-independent genome rearrangements and tumorigenesis in aging Drosophila.Genome biology · 2011Article
- Evolution of the mutation rate.Trends in genetics : TIG · 2010Article
- Age- and temperature-dependent somatic mutation accumulation in Drosophila melanogaster.PLoS genetics · 2010Article
- Article
- Lifespan extension by dietary restriction is not linked to protection against somatic DNA damage in Drosophila melanogaster.Aging cell · 2009Article
- Chaetognath transcriptome reveals ancestral and unique features among bilaterians.Genome biology · 2008Article
Corrections and comments
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Authors and funding
9 authors at 4 institutions in 2 countries.
Funding
Abstract
Presently there are no good assays for comparing somatic mutation frequencies and spectra between different vertebrate and invertebrate organisms. Here we describe a new lacZ mutation reporter system in D. melanogaster, which complements existing systems in the mouse. The results obtained with the new model indicate two-to threefold higher frequencies of spontaneous mutations than in the mouse, with most of the mutations characterized as large genome rearrangements.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.