ReviewMolecular biotechnology2007
Methods and goals for the use of in vitro and in vivo chemosensitivity testing.
Review in Molecular biotechnology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
25 citing papers in PubMed.
- Serum Metabolomic Profiles Predict Sensitivity and Toxicity to Platinum- Fluorouracil Chemotherapy in a Gastric Cancer Xenograft Model.Combinatorial chemistry & high throughput screening · 2026Article
- Flow cytometry-based targeted diagnostics for rapid assessment of daunorubicin resistance in acute myeloid leukemia.Scientific reports · 2025Article
- Antineoplastic effect of doxorubizen in vitro in continuous and primary human anaplastic thyroid cancer cells.Endocrine · 2025Article
- Article
- Treatment selection with organoids in an EGFRm + TP53m stage IA1 patient with recurrence after radical surgery.Journal of thoracic disease · 2022Article
- T-LAK cell-originated protein kinase (TOPK): an emerging prognostic biomarker and therapeutic target in osteosarcoma.Molecular oncology · 2021Article
- Neuroblastoma patient-derived cultures are enriched for a mesenchymal gene signature and reflect individual drug response.Cancer science · 2020Article
- T-LAK cell-originated protein kinase (TOPK) is a Novel Prognostic and Therapeutic Target in Chordoma.Cell proliferation · 2020Article
- Ionic Liquids Toxicity-Benefits and Threats.International journal of molecular sciences · 2020Review
- Novel treatments for anaplastic thyroid carcinoma.Gland surgery · 2020Review
- Effects of Polar Steroids from the StarfishMolecules (Basel, Switzerland) · 2019Article
- Transcriptional changes associated withAmerican journal of clinical and experimental urology · 2018Article
- Review
- Human lung adenocarcinoma cell cultures derived from malignant pleural effusions as model system to predict patients chemosensitivity.Journal of translational medicine · 2016Article
- Prediction of Cancer Drug Resistance and Implications for Personalized Medicine.Frontiers in oncology · 2015Review
- Identification of biomarkers that distinguish chemical contaminants based on gene expression profiles.BMC genomics · 2014Article
- Enhanced RegIV expression predicts the intrinsic 5-fluorouracil (5-FU) resistance in advanced gastric cancer.Digestive diseases and sciences · 2013Article
- Navigating cancer network attractors for tumor-specific therapy.Nature biotechnology · 2012Article
- RET TKI: potential role in thyroid cancers.Current oncology reports · 2012Review
- New targeted therapies for thyroid cancer.Current genomics · 2011Article
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Sensitive, specific, and accurate methods to assay chemosensitivity are needed to (1) screen new therapeutic agents, (2) identify patterns of chemosensitivity for different tumor types, (3) establish patterns of cross-resistance and sensitivity in treatment of naïve and relapsing tumors, (4) identify genomic and proteomic profiles associated with sensitivity, (5) correlate in vitro response with preclinical in vivo effects and clinical outcomes for a particular therapeutic agent, and (6) tailor chemotherapy regimens to individual patients. Various methods are available to achieve these end points, including several in vitro clonogenic and proliferation assays, cell metabolic activity assays, molecular assays to monitor expression of markers for responsiveness, drug resistance, and for induction of apoptosis, in vivo tumor growth and survival assays in metastatic and orthotopic models, and in vivo imaging assays. The advantages and disadvantages of the specific assays are discussed. A summary of research questions related to chemosensitivity testing is also included.
Indexed as
Identifiers
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.