ArticleGenetics2007
Retrotransposons influence the mouse transcriptome: implication for the divergence of genetic traits.
Article in Genetics, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
20 citing papers in PubMed, 30 citations in OpenAlex.
- Host Factors Promoting the LTR Retrotransposon Life Cycle in Plant Cells: Current Knowledge and Future Directions.International journal of molecular sciences · 2025Review
- Glial reactivity and cognitive decline follow chronic heterochromatin loss in neurons.Nature communications · 2025Article
- Longitudinal effects of developmental bisphenol A and variable diet exposures on epigenetic drift in mice.Reproductive toxicology (Elmsford, N.Y.) · 2017Article
- The structure and retrotransposition mechanism of LTR-retrotransposons in the asexual yeast Candida albicans.Virulence · 2014Review
- How do mammalian transposons induce genetic variation? A conceptual framework: the age, structure, allele frequency, and genome context of transposable elements may define their wide-ranging biological impacts.BioEssays : news and reviews in molecular, cellular and developmental biology · 2013Article
- Revisiting the evolution of mouse LINE-1 in the genomic era.Mobile DNA · 2013Article
- Article
- Mouse endogenous retroviruses can trigger premature transcriptional termination at a distance.Genome research · 2012Article
- Microarray analysis of LTR retrotransposon silencing identifies Hdac1 as a regulator of retrotransposon expression in mouse embryonic stem cells.PLoS computational biology · 2012Article
- P bodies inhibit retrotransposition of endogenous intracisternal a particles.Journal of virology · 2011Article
- Differential sensitivities of retroviruses to integrase strand transfer inhibitors.Journal of virology · 2011Article
- IAP display: a simple method to identify mouse strain specific IAP insertions.Molecular biotechnology · 2011Article
- A novel active endogenous retrovirus family contributes to genome variability in rat inbred strains.Genome research · 2010Article
- The L1 retrotransposition assay: a retrospective and toolkit.Methods (San Diego, Calif.) · 2009Review
- Remodeling yeast gene transcription by activating the Ty1 long terminal repeat retrotransposon under severe adenine deficiency.Molecular and cellular biology · 2008Article
- Extensive variation between inbred mouse strains due to endogenous L1 retrotransposition.Genome research · 2008Article
- Translation from nonautonomous type IAP retrotransposon is a critical determinant of transposition activity: implication for retrotransposon-mediated genome evolution.Genome research · 2008Article
- Microarray-based global mapping of integration sites for the retrotransposon, intracisternal A-particle, in the mouse genome.Nucleic acids research · 2008Article
- Genome-wide assessments reveal extremely high levels of polymorphism of two active families of mouse endogenous retroviral elements.PLoS genetics · 2008Article
- Transposable elements as drivers of genomic and biological diversity in vertebrates.Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology · 2008Review
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Massive accumulation of retrotransposons, comprising >40% of human and mouse genomes, is one of the major events in the evolution of the genome. However, most retrotransposons have lost retrotransposition competency, which makes studying their role in genome evolution elusive. Intracisternal A-particle (IAP) elements are long terminal repeat (LTR)-type mouse retrotransposons consisting of full-length and internally deleted types. Some are retrotransposition competent and their upregulated activity has been reported in mutant mice deficient in genome defense systems, suggesting that IAP elements provide a unique platform for studying the interaction between retrotransposons and mammalian genomes. Using the IAP element as a model case, here we show that mobilization of retrotransposons alters the mouse transcriptome. Retrotransposition assay in cultured cells demonstrated that a subset of internally deleted IAP elements, called IDelta1 type, retrotranspose efficiently when supplied with functional IAP proteins. Furthermore, the IDelta1 type IAP element exhibited substantial transcription-inducing activity in the flanking region. Genomewide transcript analysis of embryonic stem (ES) cells identified IAP-induced transcripts, including fusion transcripts between IAP sequence and endogenous genes. Unexpectedly, nearly half of these IAP elements obtained from ES cells derived from 129 mouse strain were absent in the C57BL/6 genome, suggesting that IAP-driven transcription contributes to the unique trait of the individual mouse strain. On the basis of these data, we propose that retrotransposons are one of the drivers that shape the mammalian transcriptome.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.