ArticleGenetics2007
Bayesian shrinkage analysis of quantitative trait Loci for dynamic traits.
Article in Genetics, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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Who cites it
30 citing papers in PubMed.
- Insight into Genome-Wide Associations of Growth Trajectories Using a Hierarchical Non-Linear Mixed Model.Biology · 2026Article
- Estimating genetic variance contributed by a quantitative trait locus: A random model approach.PLoS computational biology · 2022Article
- Integrating High-Throughput Phenotyping and Statistical Genomic Methods to Genetically Improve Longitudinal Traits in Crops.Frontiers in plant science · 2020Review
- Genome-wide association study identified novel candidate loci affecting wood formation in Norway spruce.The Plant journal : for cell and molecular biology · 2019Article
- A Gaussian process model and Bayesian variable selection for mapping function-valued quantitative traits with incomplete phenotypic data.Bioinformatics (Oxford, England) · 2019Article
- Functional Mapping of Quantitative Trait Loci (QTLs) Associated With Plant Performance in a Wheat MAGIC Mapping Population.Frontiers in plant science · 2018Article
- Mapping complex traits as a dynamic system.Physics of life reviews · 2015Review
- BAYESIAN GROUP LASSO FOR NONPARAMETRIC VARYING-COEFFICIENT MODELS WITH APPLICATION TO FUNCTIONAL GENOME-WIDE ASSOCIATION STUDIES.The annals of applied statistics · 2015Article
- Article
- Functional multi-locus QTL mapping of temporal trends in Scots pine wood traits.G3 (Bethesda, Md.) · 2014Article
- Identification of QTLs for Resistance to Sclerotinia sclerotiorum in Carioca Common Bean by the Moving Away Method.ISRN molecular biology · 2014Article
- Article
- Dynamic semiparametric Bayesian models for genetic mapping of complex trait with irregular longitudinal data.Statistics in medicine · 2013Article
- A decision rule for quantitative trait locus detection under the extended Bayesian LASSO model.Genetics · 2012Article
- Bayesian mapping of multiple traits in maize: the importance of pleiotropic effects in studying the inheritance of quantitative traits.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2012Article
- Simultaneous estimation of multiple quantitative trait loci and growth curve parameters through hierarchical Bayesian modeling.Heredity · 2012Article
- Article
- Bayesian functional mapping of dynamic quantitative traits.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2011Article
- A new mapping method for quantitative trait loci of silkworm.BMC genetics · 2011Article
- Article
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2 authors.
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Abstract
Many quantitative traits are measured repeatedly during the life of an organism. Such traits are called dynamic traits. The pattern of the changes of a dynamic trait is called the growth trajectory. Studying the growth trajectory may enhance our understanding of the genetic architecture of the growth trajectory. Recently, we developed an interval-mapping procedure to map QTL for dynamic traits under the maximum-likelihood framework. We fit the growth trajectory by Legendre polynomials. The method intended to map one QTL at a time and the entire QTL analysis involved scanning the entire genome by fitting multiple single-QTL models. In this study, we propose a Bayesian shrinkage analysis for estimating and mapping multiple QTL in a single model. The method is a combination between the shrinkage mapping for individual quantitative traits and the Legendre polynomial analysis for dynamic traits. The multiple-QTL model is implemented in two ways: (1) a fixed-interval approach where a QTL is placed in each marker interval and (2) a moving-interval approach where the position of a QTL can be searched in a range that covers many marker intervals. Simulation study shows that the Bayesian shrinkage method generates much better signals for QTL than the interval-mapping approach. We propose several alternative methods to present the results of the Bayesian shrinkage analysis. In particular, we found that the Wald test-statistic profile can serve as a mechanism to test the significance of a putative QTL.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.