ArticleGenetics2007
Associations between sperm competition and natural variation in male reproductive genes on the third chromosome of Drosophila melanogaster.
Article in Genetics, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 59 papers.
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Who cites it
59 citing papers in PubMed.
- No Evidence of Sexually Antagonistic Coevolution in Drosophila Reproductive Tract Transcriptomes.Molecular biology and evolution · 2025Article
- Male-derived transcripts isolated from the mated female reproductive tract in Drosophila melanogaster.G3 (Bethesda, Md.) · 2023Article
- Genotype-by-environment interactions influence the composition of theProceedings. Biological sciences · 2023Article
- Social group composition modulates the role of last male sperm precedence in post-copulatory sexual selection.Journal of evolutionary biology · 2023Article
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- The carboxypeptidase B and carbonic anhydrase genes play a reproductive regulatory role during multiple matings inFrontiers in molecular biosciences · 2023Article
- Octopaminergic/tyraminergic Tdc2 neurons regulate biased sperm usage in female Drosophila melanogaster.Genetics · 2022Article
- Seminal fluid gene expression and reproductive fitness in Drosophila melanogaster.BMC ecology and evolution · 2022Article
- ThePhilosophical transactions of the Royal Society of London. Series B, Biological sciences · 2020Review
- BMP signaling inhibition inProceedings of the National Academy of Sciences of the United States of America · 2019Article
- Seminal fluid-mediated fitness effects in the simultaneously hermaphroditic flatwormEcology and evolution · 2019Article
- Female Genetic Contributions to Sperm Competition inGenetics · 2019Article
- Genetic and environmental variation in transcriptional expression of seminal fluid proteins.Heredity · 2019Article
- Sexual conflict drives male manipulation of female postmating responses inProceedings of the National Academy of Sciences of the United States of America · 2019Article
- Winners have higher pre-copulatory mating success but losers have better post-copulatory outcomes.Proceedings. Biological sciences · 2019Article
- Genetic Factors Influencing Sperm Competition.Frontiers in genetics · 2019Review
- Symbiotic microbes affect the expression of male reproductive genes in Glossina m. morsitans.BMC microbiology · 2018Article
- Precopulatory but not postcopulatory male reproductive traits diverge in response to mating system manipulation inEcology and evolution · 2017Article
- Expression of Ciona intestinalis AOX causes male reproductive defects in Drosophila melanogaster.BMC developmental biology · 2017Article
Corrections and comments
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3 authors.
Funding
Abstract
We applied association analysis to elucidate the genetic basis for variation in phenotypes affecting postcopulatory sexual selection in a natural population of Drosophila melanogaster. We scored 96 third chromosome substitution lines for nine phenotypes affecting sperm competitive ability and genotyped them at 72 polymorphisms in 13 male reproductive genes. Significant heterogeneity among lines (P < 0.01) was detected for all phenotypes except male-induced refractoriness (P = 0.053). We identified 24 associations (8 single-marker associations, 12 three-marker haplotype associations, and 4 cases of epistasis revealed by single-marker interactions). Fewer than 9 of these associations are likely to be false positives. Several associations were consistent with previous findings [Acp70A with the male's influence on the female's refractoriness to remating (refractory), Esterase-6 with a male's remating probability (remating) and a measure of female offspring production (fecundity)], but many are novel associations with uncharacterized seminal fluid proteins. Four genes showed evidence for pleiotropic effects [CG6168 with a measure of sperm competition (P2') and refractory, CG14560 with a defensive measure of sperm competition (P1') and a measure of female fecundity, Acp62F with P2' and a measure of female fecundity, and Esterase-6 with remating and a measure of female fecundity]. Our findings provide evidence that pleiotropy and epistasis are important factors in the genetic architecture of male reproductive success and show that haplotype analyses can identify associations missed in the single-marker approach.
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