ArticleGenetics2007
Genetic modifiers of the Drosophila blue cheese gene link defects in lysosomal transport with decreased life span and altered ubiquitinated-protein profiles.
Article in Genetics, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers.
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Who cites it
46 citing papers in PubMed, 67 citations in OpenAlex.
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- Treatment with Bacterial Biologics Promotes Healthy Aging and Traumatic Brain Injury Responses in AdultCells · 2021Article
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- Dissection of Complex, Fitness-Related Traits in MultipleGenetics · 2019Article
- The BEACH Domain Is Critical for Blue Cheese Function in a Spatial and Epistatic Autophagy Hierarchy.Frontiers in cell and developmental biology · 2019Article
- Beyond autophagy: a novel role for autism-linked Wdfy3 in brain mitophagy.Scientific reports · 2018Article
- Aging and Intermittent Fasting Impact on Transcriptional Regulation and Physiological Responses of Adult Drosophila Neuronal and Muscle Tissues.International journal of molecular sciences · 2018Article
- Autophagy and Human Neurodegenerative Diseases-A Fly's Perspective.International journal of molecular sciences · 2017Review
- Differential Gene Expression Associated with Honey Bee Grooming Behavior in Response to Varroa Mites.Behavior genetics · 2017Article
- Australian black field crickets show changes in neural gene expression associated with socially-induced morphological, life-history, and behavioral plasticity.BMC genomics · 2016Article
- Genetic analysis of variation in lifespan using a multiparental advanced intercross Drosophila mapping population.BMC genetics · 2016Article
- Article
- Ceramides And Stress Signalling Intersect With Autophagic Defects In Neurodegenerative Drosophila blue cheese (bchs) Mutants.Scientific reports · 2015Article
- The lysosomal enzyme receptor protein (LERP) is not essential, but is implicated in lysosomal function in Drosophila melanogaster.Biology open · 2015Article
- A fruitful endeavor: modeling ALS in the fruit fly.Brain research · 2015Review
- Article
- Aging and Autophagic Function Influences the Progressive Decline of Adult Drosophila Behaviors.PloS one · 2015Article
- Drosophila Gyf/GRB10 interacting GYF protein is an autophagy regulator that controls neuron and muscle homeostasis.Autophagy · 2015Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Defects in lysosomal trafficking pathways lead to decreased cell viability and are associated with progressive disorders in humans. Previously we have found that loss-of-function (LOF) mutations in the Drosophila gene blue cheese (bchs) lead to reduced adult life span, increased neuronal death, and widespread CNS degeneration that is associated with the formation of ubiquitinated-protein aggregates. To identify potential genes that participate in the bchs functional pathway, we conducted a genetic modifier screen based on alterations of an eye phenotype that arises from high-level overexpression of Bchs. We found that mutations in select autophagic and endocytic trafficking genes, defects in cytoskeletal and motor proteins, as well as mutations in the SUMO and ubiquitin signaling pathways behave as modifiers of the Bchs gain-of-function (GOF) eye phenotype. Individual mutant alleles that produced viable adults were further examined for bchs-like phenotypes. Mutations in several lysosomal trafficking genes resulted in significantly decreased adult life spans and several mutants showed changes in ubiquitinated protein profiles as young adults. This work represents a novel approach to examine the role that lysosomal transport and function have on adult viability. The genes characterized in this study have direct human homologs, suggesting that similar defects in lysosomal transport may play a role in human health and age-related processes.
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