ArticleGenetics2007
Shortcut predictions for fitness properties at the mutation-selection-drift balance and for its buildup after size reduction under different management strategies.
Article in Genetics, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed.
- A Test of the Long-Term Efficiency of Genetic Rescue With Drosophila melanogaster.Molecular ecology · 2025Article
- Efficient purging of deleterious mutations contributes to the survival of a rare conifer.Horticulture research · 2024Article
- Some hope and many concerns on the future of the vaquita.Heredity · 2023Article
- Purging of deleterious burden in the endangered Iberian lynx.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Bottleneck-associated changes in the genomic landscape of genetic diversity in wild lynx populations.Evolutionary applications · 2021Article
- Article
- Detection of genetic purging and predictive value of purging parameters estimated in pedigreed populations.Heredity · 2018Article
- Sex and genotype effects on nutrient-dependent fitness landscapes inProceedings. Biological sciences · 2017Article
- Joint Prediction of the Effective Population Size and the Rate of Fixation of Deleterious Mutations.Genetics · 2016Article
- On the Consequences of Purging and Linkage on Fitness and Genetic Diversity.G3 (Bethesda, Md.) · 2015Article
- Understanding and predicting the fitness decline of shrunk populations: inbreeding, purging, mutation, and standard selection.Genetics · 2012Article
- Article
- A simple method to account for natural selection when predicting inbreeding depression.Genetics · 2008Article
Corrections and comments
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1 author.
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Abstract
For populations at the mutation-selection-drift (MSD) balance, I develop approximate analytical expressions giving expectations for the number of deleterious alleles per gamete, the number of loci at which any individual is homozygous for deleterious alleles, the inbreeding depression rate, and the additive and dominant components of fitness variance. These predictions are compared to diffusion ones, showing good agreement under a wide range of situations. I also give approximated analytical predictions for the changes in mean and additive variance for fitness when a population approaches a new equilibrium after its effective size is reduced to a stable value. Results are derived for populations maintained with equal family contribution or with no management after size reduction, when selection acts through viability or fertility differences. Predictions are compared to previously published results obtained from transition matrices or stochastic simulations, a good qualitative fit being obtained. Predictions are also obtained for populations of various sizes under different sets of plausible mutational parameters. They are compared to available empirical results for Drosophila, and conservation implications are discussed.
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