ArticleGenetics2007
Joint estimates of quantitative trait locus effect and frequency using synthetic recombinant populations of Drosophila melanogaster.
Article in Genetics, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers.
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Who cites it
43 citing papers in PubMed.
- The utility of a closed breeding colony of Peromyscus leucopus for dissecting complex traits.Genetics · 2022Article
- Powerful, efficient QTL mapping in Drosophila melanogaster using bulked phenotyping and pooled sequencing.Genetics · 2022Article
- The molecular architecture of Drosophila melanogaster defense against Beauveria bassiana explored through evolve and resequence and quantitative trait locus mapping.G3 (Bethesda, Md.) · 2021Article
- Article
- Two Synthetic 18-Way Outcrossed Populations of Diploid Budding Yeast with Utility for Complex Trait Dissection.Genetics · 2020Article
- Development of a Multiparent Population for Genetic Mapping and Allele Discovery in Six-Row Barley.Genetics · 2019Article
- Testing PleiotropyG3 (Bethesda, Md.) · 2019Article
- Article
- Article
- A Random-Model Approach to QTL Mapping in Multiparent Advanced Generation Intercross (MAGIC) Populations.Genetics · 2016Article
- Genetic and Sex-Specific Transgenerational Effects of a High Fat Diet in Drosophila melanogaster.PloS one · 2016Article
- Mapping QTL Contributing to Variation in Posterior Lobe Morphology between Strains of Drosophila melanogaster.PloS one · 2016Article
- Identifying Loci Contributing to Natural Variation in Xenobiotic Resistance in Drosophila.PLoS genetics · 2015Article
- Dissecting complex traits using the Drosophila Synthetic Population Resource.Trends in genetics : TIG · 2014Review
- Fine-mapping nicotine resistance loci in Drosophila using a multiparent advanced generation inter-cross population.Genetics · 2014Article
- Background selection as baseline for nucleotide variation across the Drosophila genome.PLoS genetics · 2014Article
- Effect of advanced intercrossing on genome structure and on the power to detect linked quantitative trait loci in a multi-parent population: a simulation study in rice.BMC genetics · 2014Article
- Abundance and distribution of transposable elements in two Drosophila QTL mapping resources.Molecular biology and evolution · 2013Article
- The genetic architecture of methotrexate toxicity is similar in Drosophila melanogaster and humans.G3 (Bethesda, Md.) · 2013Article
- Mapping quantitative trait loci onto a phylogenetic tree.Genetics · 2012Article
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We develop and implement a strategy to map QTL in two synthetic populations of Drosophila melanogaster each initiated with eight inbred founder strains. These recombinant populations allow simultaneous estimates of QTL location, effect, and frequency. Five X-linked QTL influencing bristle number were resolved to intervals of approximately 1.3 cM. We confirm previous observations of bristle number QTL distal to 4A at the tip of the chromosome and identify two novel QTL in 7F-8C, an interval that does not include any classic bristle number candidate genes. If QTL at the tip of the X are biallelic they appear to be intermediate in frequency, although there is evidence that these QTL may reside in multiallelic haplotypes. Conversely, the two QTL mapping to the middle of the X chromosome are likely rare: in each case the minor allele is observed in only 1 of the 16 founders. Assuming additivity and biallelism we estimate that identified QTL contribute 1.0 and 8.7%, respectively, to total phenotypic variation in male abdominal and sternopleural bristle number in nature. Models that seek to explain the maintenance of genetic variation make different predictions about the population frequency of QTL alleles. Thus, mapping QTL in eight-way recombinant populations can distinguish between these models.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.