ArticleGenetics2007
Identification of Mom7, a novel modifier of Apc(Min/+) on mouse chromosome 18.
Article in Genetics, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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Who cites it
30 citing papers in PubMed.
- System genetic analysis of intestinal cancer and periodontitis development as influenced by aging and diabesity using Collaborative Cross mice.Animal models and experimental medicine · 2025Review
- Pleiotropy, epistasis and the genetic architecture of quantitative traits.Nature reviews. Genetics · 2024Review
- Review
- Genetic mapping of novel modifiers for ApcBMC genomics · 2021Article
- CD36 polymorphisms and the age of disease onset in patients with pathogenic variants within the mutation cluster region of APC.Hereditary cancer in clinical practice · 2021Article
- The path to metastatic mouse models of colorectal cancer.Oncogene · 2018Review
- Article
- The Effects of Genetic Background of Mouse Models of Cancer: Friend or Foe?Cold Spring Harbor protocols · 2016Article
- Human cancer xenografts in outbred nude mice can be confounded by polymorphisms in a modifier of tumorigenesis.Genetics · 2014Article
- A strategy to identify dominant point mutant modifiers of a quantitative trait.G3 (Bethesda, Md.) · 2014Article
- More than two decades of Apc modeling in rodents.Biochimica et biophysica acta · 2013Review
- Understanding phenotypic variation in rodent models with germline Apc mutations.Cancer research · 2013Review
- What are the best routes to effectively model human colorectal cancer?Molecular oncology · 2013Review
- Mouse models for colorectal cancer.American journal of cancer research · 2013Article
- Identification of five novel modifier loci of Apc(Min) harbored in the BXH14 recombinant inbred strain.Carcinogenesis · 2012Article
- Monoallelic silencing and haploinsufficiency in early murine intestinal neoplasms.Proceedings of the National Academy of Sciences of the United States of America · 2012Article
- Article
- Modifier genes and the plasticity of genetic networks in mice.PLoS genetics · 2012Review
- Muscarinic receptor subtype-3 gene ablation and scopolamine butylbromide treatment attenuate small intestinal neoplasia in Apcmin/+ mice.Carcinogenesis · 2011Article
- Animal models of human genetic diseases: do they need to be faithful to be useful?Molecular genetics and genomics : MGG · 2011Review
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
The Apc(Min) mouse model of colorectal cancer provides a discrete, quantitative measurement of tumor multiplicity, allowing for robust quantitative trait locus analysis. This advantage has previously been used to uncover polymorphic modifiers of the Min phenotype: Mom1, which is partly explained by Pla2g2a; Mom2, a spontaneous mutant modifier; and Mom3, which was discovered in an outbred cross. Here, we describe the localization of a novel modifier, Mom7, to the pericentromeric region of chromosome 18. Mom7 was mapped in crosses involving four inbred strains: C57BL/6J (B6), BTBR/Pas (BTBR), AKR/J (AKR), and A/J. There are at least two distinct alleles of Mom7: the recessive, enhancing BTBR, AKR, and A/J alleles and the dominant, suppressive B6 allele. Homozygosity for the enhancing alleles increases tumor number by approximately threefold in the small intestine on both inbred and F(1) backgrounds. Congenic line analysis has narrowed the Mom7 region to within 7.4 Mb of the centromere, 28 Mb proximal to Apc. Analysis of SNP data from various genotyping projects suggests that the region could be as small as 4.4 Mb and that there may be five or more alleles of Mom7 segregating among the many strains of inbred mice. This has implications for experiments involving Apc(Min) and comparisons between different or mixed genetic backgrounds.
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Registered trials
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