ArticleAmerican journal of physiology. Heart and circulatory physiology2007
Adaptation of coronary microvascular exchange in arterioles and venules to exercise training and a role for sex in determining permeability responses.
Article in American journal of physiology. Heart and circulatory physiology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
16 citing papers in PubMed, 22 citations in OpenAlex.
- Microvascular Sex- and Age- Dependent Phosphodiesterase Expression.Frontiers in aging · 2021Article
- Sex differences influencing micro- and macrovascular endothelial phenotype in vitro.The Journal of physiology · 2018Article
- Microperfusion Technique to Investigate Regulation of Microvessel Permeability in Rat Mesentery.Journal of visualized experiments : JoVE · 2015Article
- Mechanosensing at the vascular interface.Annual review of biomedical engineering · 2014Review
- Emerging understanding of roles for arterioles in inflammation.Microcirculation (New York, N.Y. : 1994) · 2013Review
- Permeability and contractile responses of collecting lymphatic vessels elicited by atrial and brain natriuretic peptides.The Journal of physiology · 2013Article
- Erythrocyte-derived sphingosine-1-phosphate stabilizes basal hydraulic conductivity and solute permeability in rat microvessels.American journal of physiology. Heart and circulatory physiology · 2012Article
- Phosphodiesterase 4 inhibition attenuates plasma volume loss and transvascular exchange in volume-expanded mice.The Journal of physiology · 2012Article
- Leukocyte rolling and adhesion both contribute to regulation of microvascular permeability to albumin via ligation of ICAM-1.American journal of physiology. Cell physiology · 2011Article
- Lymphatic fluid: exchange mechanisms and regulation.The Journal of physiology · 2011Article
- Cardiovascular sex differences influencing microvascular exchange.Cardiovascular research · 2010Review
- Vascular permeability modulation at the cell, microvessel, or whole organ level: towards closing gaps in our knowledge.Cardiovascular research · 2010Review
- Intrinsic sex-specific differences in microvascular endothelial cell phosphodiesterases.American journal of physiology. Heart and circulatory physiology · 2010Article
- Leukocyte-endothelial cell interactions are linked to vascular permeability via ICAM-1-mediated signaling.American journal of physiology. Heart and circulatory physiology · 2008Article
- Counter regulatory effects of PKCbetaII and PKCdelta on coronary endothelial permeability.Arteriosclerosis, thrombosis, and vascular biology · 2008Article
- Sex-Specific Characteristics of the Microcirculation.Advances in experimental medicine and biologyReview
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Studies of physical performance and energy metabolism during and following exercise have shown significant sex-specific musculoskeletal adaptations; less is known of vascular adaptations, particularly with respect to exchange capacity. In response to adenosine (ADO), a metabolite produced during exercise, permeability (P(s)) of coronary arterioles from female pigs changed acutely; the magnitude and direction of the change (Delta P(s)) were determined by training status. In the present study P(s) to albumin was assessed in arterioles (n = 138) and venules (n = 24) isolated from hearts of male (N = 27) and female (N = 59) pigs in the exercise training group (EX). We evaluated the hypothesis that coronary microvessel exchange adapts to endurance exercise training not by altering basal P(s), per se, but by elevating P(s) on exposure to ADO. In contrast, training resulted in a reduction of basal P(s) in all arterioles, and in venules from males, with no change in venules from EX females. Exposure to ADO resulted in the predicted increase in P(s) except for venules from EX males where P(s) was reduced. Delta P(s) responses of arterioles to mediators of adenylyl cyclase (isoproterenol)- and guanylyl cyclase (atrial natriuretic peptide)-signaling pathways were attenuated in EX pigs relative to pigs in the sedentary group. The adaptation of EX arterioles involves an upregulation of a nitric oxide-dependent pathway since nitric oxide synthase inhibition blocks Delta P(s) by ADO. Thus adaptation of microvascular exchange capacity to endurance exercise training not only occurs but also involves multiple mechanisms that differ in arterioles and venules with their relative contribution to net flux being a function of sex.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.