ArticleGenetics1991
Low nucleotide diversity in man.
Article in Genetics, 1991. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 137 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
137 citing papers in PubMed.
- Tandem repeat variation within and between species reveals signatures of selection in humans and chimpanzees.bioRxiv : the preprint server for biology · 2026Article
- Article
- Previously unmeasured genetic diversity explains part of Lewontin's paradox in abioRxiv : the preprint server for biology · 2024Article
- Association between miR-146a rs2910164, miR-196a2 rs11614913, and miR-499 rs3746444 polymorphisms and the risk of esophageal carcinoma: A case-control study.Cancer medicine · 2022Article
- How Can We Resolve Lewontin's Paradox?Genome biology and evolution · 2022Article
- Misuse of the term 'trans-ethnic' in genomics research.Nature genetics · 2021Article
- Review
- Prospective avenues for human population genomics and disease mapping in southern Africa.Molecular genetics and genomics : MGG · 2020Review
- Is selecting better than modifying? An investigation of arguments against germline gene editing as compared to preimplantation genetic diagnosis.BMC medical ethics · 2019Article
- Comparative study between Helicobacter pylori and host human genetics in the Dominican Republic.BMC evolutionary biology · 2019Article
- Avian Toll-like receptor allelic diversity far exceeds human polymorphism: an insight from domestic chicken breeds.Scientific reports · 2018Article
- Better ILP models for haplotype assembly.BMC bioinformatics · 2018Article
- Nepalese Helicobacter pylori Genotypes Reflects a Geographical Diversity than a True Virulence FactorAsian Pacific journal of cancer prevention : APJCP · 2017Article
- MHC class I diversity in chimpanzees and bonobos.Immunogenetics · 2017Article
- Single-stranded DNA library preparation uncovers the origin and diversity of ultrashort cell-free DNA in plasma.Scientific reports · 2016Article
- The Nature of Genetic Variation for Complex Traits Revealed by GWAS and Regional Heritability Mapping Analyses.Genetics · 2015Article
- Genome-Wide Association Studies and Liver Disease.Seminars in liver disease · 2015Article
- Risks inherent to mitochondrial replacement.EMBO reports · 2015Article
- The Fasciola hepatica genome: gene duplication and polymorphism reveals adaptation to the host environment and the capacity for rapid evolution.Genome biology · 2015Article
- A high density GBS map of bread wheat and its application for dissecting complex disease resistance traits.BMC genomics · 2015Article
77 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The nucleotide diversity (pi) in humans is studied by using published cDNA and genomic sequences that have been carefully checked for sequencing accuracy. This measure of genetic variability is defined as the number of nucleotide differences per site between two randomly chosen sequences from a population. A total of more than 75,000 base pairs from 49 loci are compared. The DNA regions studied are the 5' and 3' untranslated regions and the amino acid coding regions. The coding regions are divided into nondegenerate sites (i.e., sites at which all possible changes are nonsynonymous), twofold degenerate sites (i.e., sites at each of which one of the three possible changes is synonymous) and fourfold degenerate sites (i.e., sites at which all three possible changes are synonymous). The pi values estimated are, respectively, 0.03 and 0.04% for the 5' and 3' UT regions, and 0.03, 0.06 and 0.11% for nondegenerate, twofold degenerate and fourfold degenerate sites. Since the highest pi value is only 0.11%, which is about one order of magnitude lower than those in Drosophila populations, the nucleotide diversity in humans is very low. The low diversity is probably due to a relatively small long-term effective population size rather than any severe bottleneck during human evolution.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.