ArticleGenetics1991
The Drosophila Broad-Complex encodes a family of related proteins containing zinc fingers.
Article in Genetics, 1991. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 143 papers.
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143 citing papers in PubMed, 440 citations in OpenAlex.
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- Neuronal identity control at the resolution of a single transcription factor isoform.bioRxiv : the preprint server for biology · 2024Article
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- BTB protein family and human breast cancer: signaling pathways and clinical progress.Journal of cancer research and clinical oncology · 2023Review
- A critical role for ecdysone response genes in regulating egg production in adult female Rhodnius prolixus.PloS one · 2023Article
- Ecdysone exerts biphasic control of regenerative signaling, coordinating the completion of regeneration with developmental progression.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Apocrine secretion in the salivary glands ofFrontiers in cell and developmental biology · 2022Article
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- Drosophila E93 promotes adult development and suppresses larval responses to ecdysone during metamorphosis.Developmental biology · 2022Article
- Regulation of metamorphosis in neopteran insects is conserved in the paleopteranProceedings of the National Academy of Sciences of the United States of America · 2021Article
- Cross-talk of insulin-like peptides, juvenile hormone, and 20-hydroxyecdysone in regulation of metabolism in the mosquitoProceedings of the National Academy of Sciences of the United States of America · 2021Article
- The Broad Transcription Factor Links Hormonal Signaling, Gene Expression, and Cellular Morphogenesis Events DuringGenetics · 2020Article
- Article
83 more citing papers are in PubMed but not listed here.
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
The Broad-Complex (BR-C) is essential for metamorphosis in Drosophila melanogaster. This locus is coextensive with the 2B5 ecdysone-responsive early puff and is necessary for puffing and transcription of many subsequently activated late genes in the developing salivary gland. Mapping of 31 cDNA clones indicates that approximately 100 kb of the genome is devoted to the synthesis of many BR-C RNAs. Sequence analyses of these cDNA clones show that the BR-C encodes a family of related proteins characterized by a common core amino-terminal domain fused to alternate carboxy domains each containing a pair of zinc fingers. Most proteins also contain domains rich in distinctive amino acids located between the common core and zinc finger regions. BR-C mutant alleles resulting from chromosomal rearrangements at 2B5 are associated with deletions of 5'-untranslated sequences, separation of the core coding domain from the downstream zinc finger domains, or a P element insertional disruption of a zinc finger coding sequence. We infer that the BR-C directly regulates late gene expression by specifying the synthesis of a family of proteins with DNA binding potential.
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